{"id":1761,"date":"2020-10-23T09:52:05","date_gmt":"2020-10-23T16:52:05","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1761"},"modified":"2020-10-26T09:52:52","modified_gmt":"2020-10-26T16:52:52","slug":"tocilizumab-in-nonventilated-patients-hospitalized-with-covid-19-pneumonia","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/23\/tocilizumab-in-nonventilated-patients-hospitalized-with-covid-19-pneumonia\/","title":{"rendered":"Tocilizumab in Nonventilated Patients Hospitalized with Covid-19 Pneumonia"},"content":{"rendered":"<ul>\n<li>[Pre-print, not peer-reviewed] The randomized, placebo-controlled multi-country EMPACTA trial indicated that tocilizumab reduced the likelihood of progression to requiring mechanical ventilation or death in patients who were hospitalized with COVID-19 pneumonia and were not on a ventilator (n=389). The cumulative proportion of patients requiring mechanical ventilation or who had died by day 28 was 12% in the tocilizumab group and 19% in the placebo groups (HR=0.56, 95%CI 0.33 \u2013 0.97). All-cause mortality by Day 28 was 10% with tocilizumab and 9% with placebo. Serious adverse events occurred in 15% of patients receiving tocilizumab and 20% of patients receiving placebo.<\/li>\n<\/ul>\n<p>Salama et al. (Oct 23, 2020). Tocilizumab in Nonventilated Patients Hospitalized with Covid-19 Pneumonia. Pre-print downloaded Oct 23 from <a href=\"https:\/\/doi.org\/10.1101\/2020.10.21.20210203\">https:\/\/doi.org\/10.1101\/2020.10.21.20210203<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] The randomized, placebo-controlled multi-country EMPACTA trial indicated that tocilizumab reduced the likelihood of progression to requiring mechanical ventilation or death in patients who were hospitalized with COVID-19 pneumonia and were not on a ventilator (n=389). The cumulative proportion of patients requiring mechanical ventilation or who had died by day 28 was 12%&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/23\/tocilizumab-in-nonventilated-patients-hospitalized-with-covid-19-pneumonia\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1761","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1761"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1761\/revisions"}],"predecessor-version":[{"id":1762,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1761\/revisions\/1762"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1761"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}