{"id":2071,"date":"2020-11-09T12:21:48","date_gmt":"2020-11-09T20:21:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2071"},"modified":"2020-11-10T12:23:49","modified_gmt":"2020-11-10T20:23:49","slug":"preexisting-and-de-novo-humoral-immunity-to-sars-cov-2-in-humans","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/09\/preexisting-and-de-novo-humoral-immunity-to-sars-cov-2-in-humans\/","title":{"rendered":"Preexisting and de Novo Humoral Immunity to SARS-CoV-2 in Humans"},"content":{"rendered":"<p>Using flow cytometry, SARS-CoV-2 spike glycoprotein (S)-reactive IgG antibodies were detected in 6 of 65 SARS-CoV-2-uninfected individuals (5 with RT-qPCR-confirmed seasonal human coronaviruses\u00a0[HCoVs] infection and 1 without recent HCoV infection). The authors conclude that this may suggest the presence of cross-reactive immunological memory from preexisting infection rather than de novo immunity.<\/p>\n<p><i>Ng et al. (Nov 6, 2020). Preexisting and de Novo Humoral Immunity to SARS-CoV-2 in Humans. Science. <\/i><a href=\"https:\/\/doi.org\/10.1126\/science.abe1107\">https:\/\/doi.org\/10.1126\/science.abe1107<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using flow cytometry, SARS-CoV-2 spike glycoprotein (S)-reactive IgG antibodies were detected in 6 of 65 SARS-CoV-2-uninfected individuals (5 with RT-qPCR-confirmed seasonal human coronaviruses\u00a0[HCoVs] infection and 1 without recent HCoV infection). The authors conclude that this may suggest the presence of cross-reactive immunological memory from preexisting infection rather than de novo immunity. Ng et al. (Nov&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/09\/preexisting-and-de-novo-humoral-immunity-to-sars-cov-2-in-humans\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-2071","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2071"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2071\/revisions"}],"predecessor-version":[{"id":2072,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2071\/revisions\/2072"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2071"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2071"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2071"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}