{"id":2100,"date":"2020-11-10T13:27:42","date_gmt":"2020-11-10T21:27:42","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2100"},"modified":"2020-11-12T13:28:36","modified_gmt":"2020-11-12T21:28:36","slug":"longitudinal-characterization-of-the-igm-and-igg-humoral-response-in-symptomatic-covid-19-patients-using-the-abbott-architect","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/10\/longitudinal-characterization-of-the-igm-and-igg-humoral-response-in-symptomatic-covid-19-patients-using-the-abbott-architect\/","title":{"rendered":"Longitudinal Characterization of the IgM and IgG Humoral Response in Symptomatic COVID-19 Patients Using the Abbott Architect"},"content":{"rendered":"<p>A longitudinal analysis of 1,349 serum samples collected up to 168 days post symptom onset from 427 individuals with PCR-confirmed COVID-19 found that IgM seroconversion occurs earlier than IgG, but that IgM levels decline to a greater extent over time. The median duration of time for IgM seroconversion was 10 days, but seroprevalence declined steadily 4-5 weeks after symptom onset down to a 31% positive after 3 months. Meanwhile, median IgG seroconversion time was 11.5 days, and despite an initial decline, is observed in 92% of patients 3-6 months after symptom onset.<\/p>\n<p><i>Maine et al. (Oct 27, 2020). Longitudinal Characterization of the IgM and IgG Humoral Response in Symptomatic COVID-19 Patients Using the Abbott Architect. Journal of Clinical Virology. <\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jcv.2020.104663\">https:\/\/doi.org\/10.1016\/j.jcv.2020.104663<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A longitudinal analysis of 1,349 serum samples collected up to 168 days post symptom onset from 427 individuals with PCR-confirmed COVID-19 found that IgM seroconversion occurs earlier than IgG, but that IgM levels decline to a greater extent over time. The median duration of time for IgM seroconversion was 10 days, but seroprevalence declined steadily&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/10\/longitudinal-characterization-of-the-igm-and-igg-humoral-response-in-symptomatic-covid-19-patients-using-the-abbott-architect\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-2100","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2100"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2100\/revisions"}],"predecessor-version":[{"id":2101,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2100\/revisions\/2101"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2100"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}