{"id":2234,"date":"2020-11-18T12:11:34","date_gmt":"2020-11-18T20:11:34","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2234"},"modified":"2020-11-19T12:13:32","modified_gmt":"2020-11-19T20:13:32","slug":"clinical-performances-of-three-fully-automated-anti-sars-cov-2-immunoassays-targeting-the-nucleocapsid-or-spike-proteins","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/18\/clinical-performances-of-three-fully-automated-anti-sars-cov-2-immunoassays-targeting-the-nucleocapsid-or-spike-proteins\/","title":{"rendered":"Clinical Performances of Three Fully Automated Anti-SARS-CoV-2 Immunoassays Targeting the Nucleocapsid or Spike Proteins"},"content":{"rendered":"<p>Both commercial spike and nucleocapsid serologic tests have approximately equivalent sensitivity for clinical diagnosis after PCR-confirmed SARS-CoV-2 infection. A study of 137 samples from 96 patients evaluating three commercial anti\u2010SARS\u2010CoV\u20102 antibody assays for the detection of COVID-19 reactive antibodies reported equivalent sensitivities (range 70.4%-85.2%) within 14 days from symptom onset to PCR-confirmed diagnosis. At 28 days following symptom onset, the sensitivity increased in all assays (range 97.5-100%). The three assays were EUROIMMUN anti\u2010SARS\u2010CoV\u20102 nucleocapsid (IgG) ELISA, Elecsys anti\u2010SARS\u2010CoV\u20102 nucleocapsid (total antibodies) assay, and LIAISON anti\u2010SARS\u2010CoV\u20102 spike proteins S1 and S2 (IgG) assay.<\/p>\n<p><i>Favresse et al. (Nov 17, 2020). Clinical Performances of Three Fully Automated Anti-SARS-CoV-2 Immunoassays Targeting the Nucleocapsid or Spike Proteins. Journal of Medical Virology. <\/i><a href=\"https:\/\/doi.org\/10.1002\/jmv.26669\">https:\/\/doi.org\/10.1002\/jmv.26669<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Both commercial spike and nucleocapsid serologic tests have approximately equivalent sensitivity for clinical diagnosis after PCR-confirmed SARS-CoV-2 infection. A study of 137 samples from 96 patients evaluating three commercial anti\u2010SARS\u2010CoV\u20102 antibody assays for the detection of COVID-19 reactive antibodies reported equivalent sensitivities (range 70.4%-85.2%) within 14 days from symptom onset to PCR-confirmed diagnosis. At 28&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/18\/clinical-performances-of-three-fully-automated-anti-sars-cov-2-immunoassays-targeting-the-nucleocapsid-or-spike-proteins\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27],"topic":[19],"class_list":["post-2234","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2234"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2234\/revisions"}],"predecessor-version":[{"id":2235,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2234\/revisions\/2235"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2234"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}