{"id":2304,"date":"2020-11-20T11:06:11","date_gmt":"2020-11-20T19:06:11","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2304"},"modified":"2020-11-23T11:20:07","modified_gmt":"2020-11-23T19:20:07","slug":"efficacy-and-safety-of-favipiravir-an-oral-rna-dependent-rna-polymerase-inhibitor-in-mild-to-moderate-covid-19-a-randomized-comparative-open-label-multicenter-phase-3-clinical-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/20\/efficacy-and-safety-of-favipiravir-an-oral-rna-dependent-rna-polymerase-inhibitor-in-mild-to-moderate-covid-19-a-randomized-comparative-open-label-multicenter-phase-3-clinical-trial\/","title":{"rendered":"Efficacy and Safety of Favipiravir, an Oral RNA-Dependent RNA Polymerase Inhibitor, in Mild-to-Moderate COVID-19: A Randomized, Comparative, Open-Label, Multicenter, Phase 3 Clinical Trial"},"content":{"rendered":"<ul>\n<li>In a randomized, multicenter, open-label, parallel-arm, Phase 3 trial of adults in India with non-severe COVID-19 (including asymptomatic patients), those who received the antiviral drug favipavir within seven days of symptoms onset had faster clinical recovery compared to placebo. Median time to clinical cure was 3 days (95%CI: 3-4 days) in those who received oral favipavir versus 5 days (95%CI: 4-6 days) in those who received placebo (p = 0.030). Median time to cessation of viral shedding was 5 days in the favipavir arm (95% CI: 4-7 days) vs 7 days in the placebo arm (95% CI: 5-8 days) (p = 0.129). Of note, the primary endpoint of this trial was viral shedding.<\/li>\n<\/ul>\n<p>Udwadia et al. (Nov 19, 2020). Efficacy and Safety of Favipiravir, an Oral RNA-Dependent RNA Polymerase Inhibitor, in Mild-to-Moderate COVID-19: A Randomized, Comparative, Open-Label, Multicenter, Phase 3 Clinical Trial. International Journal of Infectious Diseases. <a href=\"https:\/\/doi.org\/10.1016\/j.ijid.2020.11.142\">https:\/\/doi.org\/10.1016\/j.ijid.2020.11.142<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a randomized, multicenter, open-label, parallel-arm, Phase 3 trial of adults in India with non-severe COVID-19 (including asymptomatic patients), those who received the antiviral drug favipavir within seven days of symptoms onset had faster clinical recovery compared to placebo. Median time to clinical cure was 3 days (95%CI: 3-4 days) in those who received oral&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/20\/efficacy-and-safety-of-favipiravir-an-oral-rna-dependent-rna-polymerase-inhibitor-in-mild-to-moderate-covid-19-a-randomized-comparative-open-label-multicenter-phase-3-clinical-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-2304","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2304"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2304\/revisions"}],"predecessor-version":[{"id":2305,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2304\/revisions\/2305"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2304"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}