{"id":2398,"date":"2020-11-25T09:21:59","date_gmt":"2020-11-25T17:21:59","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2398"},"modified":"2020-11-30T09:24:09","modified_gmt":"2020-11-30T17:24:09","slug":"a-cluster-randomized-trial-of-hydroxychloroquine-for-prevention-of-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/25\/a-cluster-randomized-trial-of-hydroxychloroquine-for-prevention-of-covid-19\/","title":{"rendered":"A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19"},"content":{"rendered":"<ul>\n<li>An open-label, cluster-randomized trial of healthy contacts of patients with PCR\u2013confirmed SARS-CoV-2 infection in Spain found that hydroxychloroquine did not prevent infection or symptomatic COVID-19 in these individuals. The incidence of PCR-confirmed, symptomatic COVID-19 was similar between those who received hydroxychloroquine and those who received usual care (5.7% and 6.2%, respectively; RR = 0.86). Hydroxychloroquine was also not associated with a lower incidence of SARS-CoV-2 transmission (18.7% and 17.8%, respectively). The incidence of adverse events was higher in the hydroxychloroquine group than in the usual-care group (56.1% vs. 5.9%).<\/li>\n<\/ul>\n<p>Mitj\u00e0 et al. (Nov 24, 2020). A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19. New England Journal of Medicine. <a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2021801\">https:\/\/doi.org\/10.1056\/NEJMoa2021801<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An open-label, cluster-randomized trial of healthy contacts of patients with PCR\u2013confirmed SARS-CoV-2 infection in Spain found that hydroxychloroquine did not prevent infection or symptomatic COVID-19 in these individuals. The incidence of PCR-confirmed, symptomatic COVID-19 was similar between those who received hydroxychloroquine and those who received usual care (5.7% and 6.2%, respectively; RR = 0.86). Hydroxychloroquine&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/25\/a-cluster-randomized-trial-of-hydroxychloroquine-for-prevention-of-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-2398","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2398"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2398\/revisions"}],"predecessor-version":[{"id":2399,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2398\/revisions\/2399"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2398"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}