{"id":2437,"date":"2020-11-30T12:51:09","date_gmt":"2020-11-30T20:51:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2437"},"modified":"2020-12-01T12:52:37","modified_gmt":"2020-12-01T20:52:37","slug":"dynamic-changes-in-anti-sars-cov-2-antibodies-during-sars-cov-2-infection-and-recovery-from-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/30\/dynamic-changes-in-anti-sars-cov-2-antibodies-during-sars-cov-2-infection-and-recovery-from-covid-19\/","title":{"rendered":"Dynamic Changes in Anti-SARS-CoV-2 Antibodies during SARS-CoV-2 Infection and Recovery from COVID-19"},"content":{"rendered":"<p>An analysis of laboratory tests from 1850 patients hospitalized with COVID-19 showed changes in SARS-CoV-2 antibody levels over time, and that levels of spike protein (S)- or receptor-binding domain (RBD)-specific IgG were important in viral clearance and recovery. Generation of S-, RBD-, and nucleoprotein (N)-specific IgG occurred one week later in patients with severe COVID-19 compared to patients with mild\/moderate disease, while S- and RBD-specific IgG levels were 1.5-fold higher in patients with severe disease during hospitalization. During hospitalization, RBD-specific IgG levels were 4 times higher in older patients than in younger patients. Lower S-, RBD-, and N-specific IgG levels were associated with a lower lymphocyte percentage and longer viral shedding.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Li et al. (Dec 27, 2020). Dynamic Changes in Anti-SARS-CoV-2 Antibodies during SARS-CoV-2 Infection and Recovery from COVID-19. Nature Communications. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-19943-y\">https:\/\/doi.org\/10.1038\/s41467-020-19943-y<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An analysis of laboratory tests from 1850 patients hospitalized with COVID-19 showed changes in SARS-CoV-2 antibody levels over time, and that levels of spike protein (S)- or receptor-binding domain (RBD)-specific IgG were important in viral clearance and recovery. Generation of S-, RBD-, and nucleoprotein (N)-specific IgG occurred one week later in patients with severe COVID-19&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/11\/30\/dynamic-changes-in-anti-sars-cov-2-antibodies-during-sars-cov-2-infection-and-recovery-from-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[118],"topic":[31],"class_list":["post-2437","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunology","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2437"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2437\/revisions"}],"predecessor-version":[{"id":2438,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2437\/revisions\/2438"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2437"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}