{"id":2530,"date":"2020-12-03T08:09:23","date_gmt":"2020-12-03T16:09:23","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2530"},"modified":"2020-12-04T08:11:17","modified_gmt":"2020-12-04T16:11:17","slug":"intrafamilial-exposure-to-sars-cov-2-associated-with-cellular-immune-response-without-seroconversion-france","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/03\/intrafamilial-exposure-to-sars-cov-2-associated-with-cellular-immune-response-without-seroconversion-france\/","title":{"rendered":"Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France"},"content":{"rendered":"<ul>\n<li>Exposure to SARS-CoV-2 could induce virus-specific T-cell responses without inducing virus-specific antibody responses. In a study including 11 SARS-CoV-2 serodiscordant couples staying in the same household in which 1 of the 2 partners had lab-confirmed and mild symptomatic COVID-19, the index partners who were initially infected displayed SARS-CoV-2-specific antibody and T-cell responses up to 102 days after symptom onset. However, among their respective partners, none developed antibodies but 4 out of the 6 who developed COVID-19 symptoms displayed positive T-cell responses. The authors conclude that these T-cell responses provide evidence that transient or anatomically contained SARS-CoV-2 infection may have occurred and that T-cell responses could be more sensitive indicators of SARS-Co-V-2 exposure than antibodies.<\/li>\n<\/ul>\n<p>Gallais et al. (Nov 30, 2021). Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France. Emerging Infectious Diseases. <a href=\"https:\/\/doi.org\/10.3201\/eid2701.203611\">https:\/\/doi.org\/10.3201\/eid2701.203611<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Exposure to SARS-CoV-2 could induce virus-specific T-cell responses without inducing virus-specific antibody responses. In a study including 11 SARS-CoV-2 serodiscordant couples staying in the same household in which 1 of the 2 partners had lab-confirmed and mild symptomatic COVID-19, the index partners who were initially infected displayed SARS-CoV-2-specific antibody and T-cell responses up to 102&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/03\/intrafamilial-exposure-to-sars-cov-2-associated-with-cellular-immune-response-without-seroconversion-france\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-2530","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2530"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2530\/revisions"}],"predecessor-version":[{"id":2531,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2530\/revisions\/2531"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2530"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}