{"id":2621,"date":"2020-12-08T12:15:14","date_gmt":"2020-12-08T20:15:14","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2621"},"modified":"2020-12-09T12:16:06","modified_gmt":"2020-12-09T20:16:06","slug":"hydroxychloroquine-as-postexposure-prophylaxis-to-prevent-severe-acute-respiratory-syndrome-coronavirus-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/08\/hydroxychloroquine-as-postexposure-prophylaxis-to-prevent-severe-acute-respiratory-syndrome-coronavirus-2-infection\/","title":{"rendered":"Hydroxychloroquine as Postexposure Prophylaxis to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Infection"},"content":{"rendered":"<p>In a US household-randomized, double-blind, placebo-controlled trial among PCR-negative close contacts of persons with confirmed SARS-CoV-2 infection (n=689), no difference in SARS-CoV-2 acquisition by day 14 was observed between those receiving hydroxychloroquine post-exposure prophylaxis or placebo (HR = 1.10, 95% CI = 0.73-1.66). More participants in the hydroxychloroquine group experienced adverse events, including gastrointestinal symptoms and rash, compared to the control group (16.2% vs 10.9%, p = 0.026).<\/p>\n<p><i>Barnabas et al. (Dec 8, 2020). Hydroxychloroquine as Postexposure Prophylaxis to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Annals of Internal Medicine. <\/i><a href=\"https:\/\/doi.org\/10.7326\/M20-6519\">https:\/\/doi.org\/10.7326\/M20-6519<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a US household-randomized, double-blind, placebo-controlled trial among PCR-negative close contacts of persons with confirmed SARS-CoV-2 infection (n=689), no difference in SARS-CoV-2 acquisition by day 14 was observed between those receiving hydroxychloroquine post-exposure prophylaxis or placebo (HR = 1.10, 95% CI = 0.73-1.66). More participants in the hydroxychloroquine group experienced adverse events, including gastrointestinal symptoms&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/08\/hydroxychloroquine-as-postexposure-prophylaxis-to-prevent-severe-acute-respiratory-syndrome-coronavirus-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-2621","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2621"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2621\/revisions"}],"predecessor-version":[{"id":2622,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2621\/revisions\/2622"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2621"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}