{"id":2730,"date":"2020-12-14T12:15:19","date_gmt":"2020-12-14T20:15:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2730"},"modified":"2020-12-15T12:16:16","modified_gmt":"2020-12-15T20:16:16","slug":"baricitinib-plus-remdesivir-for-hospitalized-adults-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/14\/baricitinib-plus-remdesivir-for-hospitalized-adults-with-covid-19\/","title":{"rendered":"Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19"},"content":{"rendered":"<p>Receiving baricitinib, a kinase inhibitor that blocks a cytokine signaling pathway, in addition to remdesivir, was associated with shorter recovery time (median 7 vs. 8 days, RR=1.2) and higher odds of improvement at day 15 (OR=1.3) in a double-blind, randomized, placebo-controlled trial\u00a0involving 1,033 patients hospitalized with COVID-19. The estimate for the risk of death through 28 days was lower in the combination group, but was not statistically significant (HR=0.65, 95% CI 0.39-1.09). Serious adverse events were less frequent with the combination therapy (16% vs. 21%, p=0.03).<\/p>\n<p><i>Kalil et al. (Dec 11, 2020). Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. The New England Journal of Medicine. <\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2031994\">https:\/\/doi.org\/10.1056\/NEJMoa2031994<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Receiving baricitinib, a kinase inhibitor that blocks a cytokine signaling pathway, in addition to remdesivir, was associated with shorter recovery time (median 7 vs. 8 days, RR=1.2) and higher odds of improvement at day 15 (OR=1.3) in a double-blind, randomized, placebo-controlled trial\u00a0involving 1,033 patients hospitalized with COVID-19. The estimate for the risk of death through&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/14\/baricitinib-plus-remdesivir-for-hospitalized-adults-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-2730","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2730"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2730\/revisions"}],"predecessor-version":[{"id":2731,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2730\/revisions\/2731"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2730"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}