{"id":2789,"date":"2020-12-16T11:43:30","date_gmt":"2020-12-16T19:43:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2789"},"modified":"2020-12-17T11:44:37","modified_gmt":"2020-12-17T19:44:37","slug":"clinical-laboratory-and-temporal-predictors-of-neutralizing-antibodies-to-sars-cov-2-among-covid-19-convalescent-plasma-donor-candidates","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/16\/clinical-laboratory-and-temporal-predictors-of-neutralizing-antibodies-to-sars-cov-2-among-covid-19-convalescent-plasma-donor-candidates\/","title":{"rendered":"Clinical, Laboratory, and Temporal Predictors of Neutralizing Antibodies to SARS-CoV-2 among COVID-19 Convalescent Plasma Donor Candidates"},"content":{"rendered":"<p>A study assessing the durability of neutralizing antibody responses (nAb) and factors to streamline plasma donor selection found that nAb titers correlated with COVID-19 severity (aOR=6.59), age (aOR=1.03 per year), and male sex (aOR=2.08). Functional levels declined over time and a small number of individuals (2.8%) who recovered from COVID-19 lacked adaptive immune responses. Of 250 people studied a mean of 67 days after symptom onset, 97% were seropositive on at least one assay.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Boonyaratanakornkit et al. (Dec 15, 2020). Clinical, Laboratory, and Temporal Predictors of Neutralizing Antibodies to SARS-CoV-2 among COVID-19 Convalescent Plasma Donor Candidates. Journal of Clinical Investigation. <\/i><a href=\"https:\/\/doi.org\/10.1172\/JCI144930\">https:\/\/doi.org\/10.1172\/JCI144930<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study assessing the durability of neutralizing antibody responses (nAb) and factors to streamline plasma donor selection found that nAb titers correlated with COVID-19 severity (aOR=6.59), age (aOR=1.03 per year), and male sex (aOR=2.08). Functional levels declined over time and a small number of individuals (2.8%) who recovered from COVID-19 lacked adaptive immune responses. Of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/16\/clinical-laboratory-and-temporal-predictors-of-neutralizing-antibodies-to-sars-cov-2-among-covid-19-convalescent-plasma-donor-candidates\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-2789","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2789"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2789\/revisions"}],"predecessor-version":[{"id":2790,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2789\/revisions\/2790"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2789"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}