{"id":2912,"date":"2020-12-23T12:16:57","date_gmt":"2020-12-23T20:16:57","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2912"},"modified":"2020-12-24T12:18:03","modified_gmt":"2020-12-24T20:18:03","slug":"multiplex-assays-for-the-identification-of-serological-signatures-of-sars-cov-2-infection-an-antibody-based-diagnostic-and-machine-learning-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/23\/multiplex-assays-for-the-identification-of-serological-signatures-of-sars-cov-2-infection-an-antibody-based-diagnostic-and-machine-learning-study\/","title":{"rendered":"Multiplex Assays for the Identification of Serological Signatures of SARS-CoV-2 Infection: An Antibody-Based Diagnostic and Machine Learning Study"},"content":{"rendered":"<p>Testing for multiple biomarkers, as opposed to testing for a single antibody, increased the sensitivity of correctly identifying past SARS-CoV-2 infection. A multiplex serological assay was used to measure IgG and IgM antibody responses to seven SARS-CoV-2-specific antigens, two seasonal coronavirus antigens, and three non-coronavirus antigens. Antibodies were measured in serum samples collected up to 39 days after symptom onset from 215 adults with RT-PCR-confirmed COVID-19. The results suggest that IgG antibody levels to a single antigen can classify samples from individuals previously infected with SARS-CoV-2 with 92% sensitivity and 99% specificity. Measuring additional biomarkers with a multiplex assay can improve classification performance to 99% sensitivity and 99% specificity.<\/p>\n<p><i>Rosado et al. (Dec 23, 2020). Multiplex Assays for the Identification of Serological Signatures of SARS-CoV-2 Infection: An Antibody-Based Diagnostic and Machine Learning Study. The Lancet Microbe. <\/i><a href=\"https:\/\/doi.org\/10.1016\/S2666-5247(20)30197-X\">https:\/\/doi.org\/10.1016\/S2666-5247(20)30197-X<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Testing for multiple biomarkers, as opposed to testing for a single antibody, increased the sensitivity of correctly identifying past SARS-CoV-2 infection. A multiplex serological assay was used to measure IgG and IgM antibody responses to seven SARS-CoV-2-specific antigens, two seasonal coronavirus antigens, and three non-coronavirus antigens. Antibodies were measured in serum samples collected up to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/23\/multiplex-assays-for-the-identification-of-serological-signatures-of-sars-cov-2-infection-an-antibody-based-diagnostic-and-machine-learning-study\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[25,75,76,27],"topic":[19],"class_list":["post-2912","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-candidate","tag-report","tag-summarize","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2912"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2912\/revisions"}],"predecessor-version":[{"id":2913,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2912\/revisions\/2913"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2912"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}