{"id":2920,"date":"2020-12-23T12:23:42","date_gmt":"2020-12-23T20:23:42","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=2920"},"modified":"2020-12-24T12:24:59","modified_gmt":"2020-12-24T20:24:59","slug":"assessment-of-maternal-and-neonatal-sars-cov-2-viral-load-transplacental-antibody-transfer-and-placental-pathology-in-pregnancies-during-the-covid-19-pandemic","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/23\/assessment-of-maternal-and-neonatal-sars-cov-2-viral-load-transplacental-antibody-transfer-and-placental-pathology-in-pregnancies-during-the-covid-19-pandemic\/","title":{"rendered":"Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic"},"content":{"rendered":"<p>A prospective cohort study of 127 pregnant women found inefficient transplacental transfer of maternal SARS-CoV-2 specific antibodies and no evidence for prolonged viremia in either maternal or fetal circulation. No detectable viremia in maternal or cord blood was identified in 64 participants diagnosed with COVID-19 and no SARS-CoV-2 RNA was detected in 88 tested placentas. Among 77 mother-infant dyads in whom antibodies were quantified in cord blood and maternal circulation, the ratio of maternal to fetal SARS-CoV-2-specific IgG was lower than the maternal to fetal ratio of influenza A (hemagglutinin)-specific IgG, which the authors suggest reflects inefficient transfer.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Edlow et al. (Dec 22, 2020). Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Network Open. <\/i><a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.30455\">https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.30455<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A prospective cohort study of 127 pregnant women found inefficient transplacental transfer of maternal SARS-CoV-2 specific antibodies and no evidence for prolonged viremia in either maternal or fetal circulation. No detectable viremia in maternal or cord blood was identified in 64 participants diagnosed with COVID-19 and no SARS-CoV-2 RNA was detected in 88 tested placentas&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/12\/23\/assessment-of-maternal-and-neonatal-sars-cov-2-viral-load-transplacental-antibody-transfer-and-placental-pathology-in-pregnancies-during-the-covid-19-pandemic\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[25,75,76,38],"topic":[31],"class_list":["post-2920","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-candidate","tag-report","tag-summarize","tag-transmission","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=2920"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2920\/revisions"}],"predecessor-version":[{"id":2921,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/2920\/revisions\/2921"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=2920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=2920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=2920"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=2920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}