{"id":3087,"date":"2021-01-07T12:40:51","date_gmt":"2021-01-07T20:40:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3087"},"modified":"2021-01-08T12:42:47","modified_gmt":"2021-01-08T20:42:47","slug":"early-high-titer-plasma-therapy-to-prevent-severe-covid-19-in-older-adults","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/early-high-titer-plasma-therapy-to-prevent-severe-covid-19-in-older-adults\/","title":{"rendered":"Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults"},"content":{"rendered":"<p>In a randomized, double-blind, placebo-controlled trial of non-hospitalized adults aged \u226575 years (n=160) with mild COVID-19, patients who received convalescent plasma within 72 hours after onset of symptoms were 48% less likely to develop severe respiratory disease than patients receiving placebo (RR = 0.52, 95% CI: 0.29-0.94). Risk of severe disease was 60% lower (RR = 0.40, 95% CI: 0.20-0.81) when patients who developed severe respiratory disease before infusion of treatment or placebo were excluded.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Libster et al. (Jan 6, 2021). Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. New England Journal of Medicine. <\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2033700\">https:\/\/doi.org\/10.1056\/NEJMoa2033700<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a randomized, double-blind, placebo-controlled trial of non-hospitalized adults aged \u226575 years (n=160) with mild COVID-19, patients who received convalescent plasma within 72 hours after onset of symptoms were 48% less likely to develop severe respiratory disease than patients receiving placebo (RR = 0.52, 95% CI: 0.29-0.94). Risk of severe disease was 60% lower (RR&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/early-high-titer-plasma-therapy-to-prevent-severe-covid-19-in-older-adults\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-3087","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3087"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3087\/revisions"}],"predecessor-version":[{"id":3088,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3087\/revisions\/3088"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3087"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}