{"id":3089,"date":"2021-01-07T12:43:12","date_gmt":"2021-01-07T20:43:12","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3089"},"modified":"2021-01-08T12:44:46","modified_gmt":"2021-01-08T20:44:46","slug":"immunological-memory-to-sars-cov-2-assessed-for-up-to-8-months-after-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/immunological-memory-to-sars-cov-2-assessed-for-up-to-8-months-after-infection\/","title":{"rendered":"Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection"},"content":{"rendered":"<p>IgG antibodies against the Spike protein and the receptor binding domain (RBD) were relatively stable over 6 months in a cohort study of individuals with confirmed COVID-19 (n=188). Among 40 individuals with blood samples 6-8 months post-symptom onset, 90%, 88%, and 90% remained seropositive for anti-spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Paired timepoint analysis showed that anti-spike and anti-RBD IgG declined with a half-life of 68 and 69 days, respectively. Spike-specific memory B cells were more abundant at 6 months than at 1 month post-symptom onset, while SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months.<\/p>\n<p><i>Dan et al. (Jan 6, 2021). Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection. Science. <\/i><a href=\"https:\/\/doi.org\/10.1126\/science.abf4063\">https:\/\/doi.org\/10.1126\/science.abf4063<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>IgG antibodies against the Spike protein and the receptor binding domain (RBD) were relatively stable over 6 months in a cohort study of individuals with confirmed COVID-19 (n=188). Among 40 individuals with blood samples 6-8 months post-symptom onset, 90%, 88%, and 90% remained seropositive for anti-spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Paired timepoint&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/immunological-memory-to-sars-cov-2-assessed-for-up-to-8-months-after-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-3089","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3089"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3089\/revisions"}],"predecessor-version":[{"id":3090,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3089\/revisions\/3090"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3089"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}