{"id":3091,"date":"2021-01-07T12:45:10","date_gmt":"2021-01-07T20:45:10","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3091"},"modified":"2021-01-08T12:46:20","modified_gmt":"2021-01-08T20:46:20","slug":"a-longitudinal-study-of-sars-cov-2-infected-patients-reveals-a-high-correlation-between-neutralizing-antibodies-and-covid-19-severity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/a-longitudinal-study-of-sars-cov-2-infected-patients-reveals-a-high-correlation-between-neutralizing-antibodies-and-covid-19-severity\/","title":{"rendered":"A Longitudinal Study of SARS-CoV-2-Infected Patients Reveals a High Correlation between Neutralizing Antibodies and COVID-19 Severity"},"content":{"rendered":"<p>Serum samples from a cohort of 140 SARS-CoV-2 positive patients suggest that increasing symptom severity is correlated with higher neutralizing antibody (nAb) titers. Only 1 of 44 patients admitted to the ICU did not develop a nAb response by the time of sampling, while nAb response was more heterogenous and less frequently observed among hospitalized non-ICU patients and outpatients. Further analysis of the serum samples also showed an absence of cross-reactivity to other coronaviruses, and no effect of the D614G mutation on neutralization activity.<\/p>\n<p><i>Legros et al. (Jan 6, 2021). A Longitudinal Study of SARS-CoV-2-Infected Patients Reveals a High Correlation between Neutralizing Antibodies and COVID-19 Severity. Cellular &amp; Molecular Immunology. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41423-020-00588-2\">https:\/\/doi.org\/10.1038\/s41423-020-00588-2<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Serum samples from a cohort of 140 SARS-CoV-2 positive patients suggest that increasing symptom severity is correlated with higher neutralizing antibody (nAb) titers. Only 1 of 44 patients admitted to the ICU did not develop a nAb response by the time of sampling, while nAb response was more heterogenous and less frequently observed among hospitalized&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/07\/a-longitudinal-study-of-sars-cov-2-infected-patients-reveals-a-high-correlation-between-neutralizing-antibodies-and-covid-19-severity\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-3091","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3091"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3091\/revisions"}],"predecessor-version":[{"id":3092,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3091\/revisions\/3092"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3091"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}