Among hospitalized adults treated with convalescent plasma, death within 30 days occurred in 115 of 515 (22%) patients in the group that received a product with a high titer of anti-spike IgG antibodies, 549 of 2006 (27%) patients in the medium-titer group, and 166 of 561 (30%) patients in the low-titer group. The relationship differed by mechanical ventilation status. Participants who were not mechanically ventilated had a lower risk of death in the high-titer group versus the low-titer group (aRR=0.66, 95%CI 0.48-0.91), but there was no significant difference among patients who were receiving mechanical ventilation (aRR=1.02, 95% CI 0.78-1.32). Additionally, participants who received convalescent plasma within 3 days of diagnosis had lower risk of death than those who were transfused later. The analysis is based on a national registry.<\/p>\n
Joyner et al. (Jan 13, 2021). Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19. New England Journal of Medicine. <\/i>https:\/\/doi.org\/10.1056\/NEJMoa2031893<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Among hospitalized adults treated with convalescent plasma, death within 30 days occurred in 115 of 515 (22%) patients in the group that received a product with a high titer of anti-spike IgG antibodies, 549 of 2006 (27%) patients in the medium-titer group, and 166 of 561 (30%) patients in the low-titer group. The relationship differed…<\/p>\n