{"id":3274,"date":"2021-01-15T21:55:30","date_gmt":"2021-01-16T05:55:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3274"},"modified":"2021-01-16T21:56:00","modified_gmt":"2021-01-17T05:56:00","slug":"circulating-mitochondrial-dna-is-an-early-indicator-of-severe-illness-and-mortality-from-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/15\/circulating-mitochondrial-dna-is-an-early-indicator-of-severe-illness-and-mortality-from-covid-19\/","title":{"rendered":"Circulating Mitochondrial DNA Is an Early Indicator of Severe Illness and Mortality from COVID-19"},"content":{"rendered":"<p>Elevated mitochondrial DNA levels measured within 24 hours of presentation were associated with mortality, ICU admission, intubation, vasopressor use, and renal replacement therapy in patients hospitalized with COVID-19. These associations were maintained after adjustment for age, sex, and comorbidities. Circulating mitochondrial DNA levels demonstrate similar or improved sensitivity over clinically established measurements for assessing potential outcomes for COVID-19 patients.<\/p>\n<p><i>Scozzi et al. (Jan 14, 2021). Circulating Mitochondrial DNA Is an Early Indicator of Severe Illness and Mortality from COVID-19. JCI Insight. <\/i><a href=\"https:\/\/doi.org\/10.1172\/jci.insight.143299\">https:\/\/doi.org\/10.1172\/jci.insight.143299<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elevated mitochondrial DNA levels measured within 24 hours of presentation were associated with mortality, ICU admission, intubation, vasopressor use, and renal replacement therapy in patients hospitalized with COVID-19. These associations were maintained after adjustment for age, sex, and comorbidities. Circulating mitochondrial DNA levels demonstrate similar or improved sensitivity over clinically established measurements for assessing potential&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/15\/circulating-mitochondrial-dna-is-an-early-indicator-of-severe-illness-and-mortality-from-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,63],"topic":[20],"class_list":["post-3274","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-mortality","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3274"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3274\/revisions"}],"predecessor-version":[{"id":3276,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3274\/revisions\/3276"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3274"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}