{"id":3299,"date":"2021-01-19T10:26:06","date_gmt":"2021-01-19T18:26:06","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3299"},"modified":"2021-01-20T10:26:55","modified_gmt":"2021-01-20T18:26:55","slug":"evolution-of-antibody-immunity-to-sars-cov-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/19\/evolution-of-antibody-immunity-to-sars-cov-2\/","title":{"rendered":"Evolution of Antibody Immunity to SARS-CoV-2"},"content":{"rendered":"<p>Serological analysis in a cohort of 87 SARS-CoV-2 recovered individuals show that between 1.3 and 6.2 months after infection, IgM and IgG anti-spike receptor binding domain (RBD) antibody titers decrease, and neutralizing activity declines by 5-fold. In contrast, levels of RBD-specific memory B cells remain largely unchanged. Antibodies expressed by the memory B cells at 6.2 months have greater somatic hypermutation, increased potency and resistance to RBD mutations, which is indicative of an evolving immune response to SARS-CoV-2.<\/p>\n<p><i>Gaebler et al. (Jan 18, 2021). Evolution of Antibody Immunity to SARS-CoV-2. Nature. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03207-w\">https:\/\/doi.org\/10.1038\/s41586-021-03207-w<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Serological analysis in a cohort of 87 SARS-CoV-2 recovered individuals show that between 1.3 and 6.2 months after infection, IgM and IgG anti-spike receptor binding domain (RBD) antibody titers decrease, and neutralizing activity declines by 5-fold. In contrast, levels of RBD-specific memory B cells remain largely unchanged. Antibodies expressed by the memory B cells at&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/19\/evolution-of-antibody-immunity-to-sars-cov-2\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-3299","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3299"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3299\/revisions"}],"predecessor-version":[{"id":3300,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3299\/revisions\/3300"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3299"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}