{"id":3416,"date":"2021-01-25T11:27:05","date_gmt":"2021-01-25T19:27:05","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3416"},"modified":"2021-02-22T22:14:47","modified_gmt":"2021-02-23T06:14:47","slug":"mrna-1273-vaccine-induces-neutralizing-antibodies-against-spike-mutants-from-global-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/25\/mrna-1273-vaccine-induces-neutralizing-antibodies-against-spike-mutants-from-global-sars-cov-2-variants\/","title":{"rendered":"MRNA-1273 Vaccine Induces Neutralizing Antibodies against Spike Mutants from Global SARS-CoV-2 Variants"},"content":{"rendered":"<p><i>[Pre-print, not peer-reviewed]<\/i> Sera from human subjects or non-human primates (NHPs) that received the mRNA-1273 (Moderna) vaccine showed no significant reduction in neutralization activity against the SARS-CoV-2 B.1.1.7 variant emerging from the UK, but reduced activity against the B.1.351 variant emerging from South Africa. The study used two pseudovirus neutralization assays expressing spike proteins of different SARS-CoV-2 variants, and found that pseudoviruses with spike containing K417N-E484K-N501Y-D614G and full B.1.351 mutations resulted in 2.7 and 6.4-fold geometric mean titer (GMT) reduction, respectively, when compared to the D614G pseudovirus. The GMT of these human sera to the full B.1.351 spike variant was 1\/290; all evaluated sera were able to fully neutralize.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Wu et al. (Jan 25, 2021). MRNA-1273 Vaccine Induces Neutralizing Antibodies against Spike Mutants from Global SARS-CoV-2 Variants. Pre-print downloaded Jan 25 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.01.25.427948\">https:\/\/doi.org\/10.1101\/2021.01.25.427948<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Sera from human subjects or non-human primates (NHPs) that received the mRNA-1273 (Moderna) vaccine showed no significant reduction in neutralization activity against the SARS-CoV-2 B.1.1.7 variant emerging from the UK, but reduced activity against the B.1.351 variant emerging from South Africa. The study used two pseudovirus neutralization assays expressing spike proteins of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/25\/mrna-1273-vaccine-induces-neutralizing-antibodies-against-spike-mutants-from-global-sars-cov-2-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33,159],"topic":[31],"class_list":["post-3416","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3416"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3416\/revisions"}],"predecessor-version":[{"id":3417,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3416\/revisions\/3417"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3416"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}