{"id":3443,"date":"2021-01-26T13:42:09","date_gmt":"2021-01-26T21:42:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3443"},"modified":"2021-01-27T13:43:00","modified_gmt":"2021-01-27T21:43:00","slug":"longitudinal-analysis-of-humoral-immunity-against-sars-cov-2-spike-in-convalescent-individuals-up-to-8-months-post-symptom-onset","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/26\/longitudinal-analysis-of-humoral-immunity-against-sars-cov-2-spike-in-convalescent-individuals-up-to-8-months-post-symptom-onset\/","title":{"rendered":"Longitudinal Analysis of Humoral Immunity against SARS-CoV-2 Spike in Convalescent Individuals up to 8 Months Post-Symptom Onset"},"content":{"rendered":"<p><i>[Pre-print, not peer-reviewed]<\/i> A longitudinal study of 101 blood samples from 32 people recovering from COVID-19 found that memory B cells for anti-receptor binding domain (RBD) IgG antibodies increase over time and persist for up to 8 months post-symptom onset. Detectable IgG and sustained Fc-effector activity in plasma was also observed up to 8 months, despite IgG levels decaying over time. In contrast, levels of RBD-specific IgM memory B cells and IgM antibodies waned much more rapidly than their IgG counterparts.<\/p>\n<p><i>Anand et al. (Jan 25, 2021). Longitudinal Analysis of Humoral Immunity against SARS-CoV-2 Spike in Convalescent Individuals up to 8 Months Post-Symptom Onset. Pre-print downloaded Jan 26 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.01.25.428097\">https:\/\/doi.org\/10.1101\/2021.01.25.428097<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A longitudinal study of 101 blood samples from 32 people recovering from COVID-19 found that memory B cells for anti-receptor binding domain (RBD) IgG antibodies increase over time and persist for up to 8 months post-symptom onset. Detectable IgG and sustained Fc-effector activity in plasma was also observed up to 8 months,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/26\/longitudinal-analysis-of-humoral-immunity-against-sars-cov-2-spike-in-convalescent-individuals-up-to-8-months-post-symptom-onset\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-3443","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3443"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3443\/revisions"}],"predecessor-version":[{"id":3444,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3443\/revisions\/3444"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3443"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}