{"id":3523,"date":"2021-01-28T19:41:56","date_gmt":"2021-01-29T03:41:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3523"},"modified":"2021-01-29T19:43:14","modified_gmt":"2021-01-30T03:43:14","slug":"neutralization-of-spike-6970-deletion-e484k-and-n501y-sars-cov-2-by-bnt162b2-vaccine-elicited-sera","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/28\/neutralization-of-spike-6970-deletion-e484k-and-n501y-sars-cov-2-by-bnt162b2-vaccine-elicited-sera\/","title":{"rendered":"Neutralization of Spike 6970 Deletion E484K and N501Y SARS-CoV-2 by BNT162b2 Vaccine-Elicited Sera"},"content":{"rendered":"<p><i>[Pre-print, not peer-reviewed]<\/i> Sera from recipients who completed the 2-dose regimen of the Pfizer vaccine BNT162b2 (n=20) had similar neutralizing geometric mean titers (GMTs) against SARS-CoV-2 viruses engineered to contain key spike protein mutations from variants emerging from the UK (B.1.1.7) and South Africa (B.1.351) compared to GMTs against the wild-type virus. Compared to the GMTs against the wild-type virus, GMTs against viruses with the N501Y mutation (present in both variants) and the key B.1.1.7 mutations (\u039469\/70+N501Y+D614G) were 1.46- and 1.41-fold higher, respectively. In contrast, GMTs against the key B.1.351 mutations (E484K+N501Y+D614G) were 19% lower than wild-type. The authors note that the engineered viruses do not contain the full set of mutations present in variants B.1.1.7 and B.1.351.<\/p>\n<p><i>Xie et al. (Jan 27, 2021). Neutralization of Spike 6970 Deletion E484K and N501Y SARS-CoV-2 by BNT162b2 Vaccine-Elicited Sera. Pre-print downloaded Jan 28 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.01.27.427998\">https:\/\/doi.org\/10.1101\/2021.01.27.427998<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Sera from recipients who completed the 2-dose regimen of the Pfizer vaccine BNT162b2 (n=20) had similar neutralizing geometric mean titers (GMTs) against SARS-CoV-2 viruses engineered to contain key spike protein mutations from variants emerging from the UK (B.1.1.7) and South Africa (B.1.351) compared to GMTs against the wild-type virus. Compared to the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/28\/neutralization-of-spike-6970-deletion-e484k-and-n501y-sars-cov-2-by-bnt162b2-vaccine-elicited-sera\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33,159],"topic":[31],"class_list":["post-3523","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3523"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3523\/revisions"}],"predecessor-version":[{"id":3525,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3523\/revisions\/3525"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3523"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}