{"id":3549,"date":"2021-01-29T20:08:11","date_gmt":"2021-01-30T04:08:11","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3549"},"modified":"2021-02-22T22:12:57","modified_gmt":"2021-02-23T06:12:57","slug":"sars-cov-2-variant-b-1-1-7-is-susceptible-to-neutralizing-antibodies-elicited-by-ancestral-spike-vaccines","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/29\/sars-cov-2-variant-b-1-1-7-is-susceptible-to-neutralizing-antibodies-elicited-by-ancestral-spike-vaccines\/","title":{"rendered":"SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines"},"content":{"rendered":"<p><i>[Pre-print, not peer-reviewed]<\/i> Using a lentivirus-based pseudovirus assay, the SARS-CoV-2 B.1.1.7 (UK) variant was shown to exhibit only modestly reduced susceptibility to neutralization from convalescent sera (1.5-fold average reduction) and sera from recipients of both the Moderna and Novavax vaccine phase 1 studies (2-fold average reduction after two inoculations. The authors used the prototypic D614G variant as a comparator.<\/p>\n<p><i>Cheng et al. (Jan 28, 2021). SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines. Pre-print downloaded Jan 29 from<span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1101\/2021.01.27.428516\">https:\/\/doi.org\/10.1101\/2021.01.27.428516<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Using a lentivirus-based pseudovirus assay, the SARS-CoV-2 B.1.1.7 (UK) variant was shown to exhibit only modestly reduced susceptibility to neutralization from convalescent sera (1.5-fold average reduction) and sera from recipients of both the Moderna and Novavax vaccine phase 1 studies (2-fold average reduction after two inoculations. The authors used the prototypic D614G&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/01\/29\/sars-cov-2-variant-b-1-1-7-is-susceptible-to-neutralizing-antibodies-elicited-by-ancestral-spike-vaccines\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33,159],"topic":[31],"class_list":["post-3549","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3549"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3549\/revisions"}],"predecessor-version":[{"id":3550,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3549\/revisions\/3550"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3549"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}