{"id":3664,"date":"2021-02-03T22:15:22","date_gmt":"2021-02-04T06:15:22","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3664"},"modified":"2021-02-03T22:15:22","modified_gmt":"2021-02-04T06:15:22","slug":"the-limit-of-detection-matters-the-case-for-benchmarking-severe-acute-respiratory-syndrome-coronavirus-2-testing","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/03\/the-limit-of-detection-matters-the-case-for-benchmarking-severe-acute-respiratory-syndrome-coronavirus-2-testing\/","title":{"rendered":"The Limit of Detection Matters: The Case for Benchmarking Severe Acute Respiratory Syndrome Coronavirus 2 Testing"},"content":{"rendered":"<p>A study modeling the clinical sensitivity of assays to detect SARS-CoV-2 based on their limits of detection (LoD) found that each 10-fold increase in LoD was expected to lower the assay sensitivity by about 13%. Ct values were obtained from 4,700 SARS-CoV-2 positive patients using the Abbott SARS-CoV-2 EUA test. The authors argue that assays with the highest LoD\u2019s (i.e. incapable of detecting low copy numbers) will miss a majority of infected individuals.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Arnaout et al. (Feb 3, 2020). The Limit of Detection Matters: The Case for Benchmarking Severe Acute Respiratory Syndrome Coronavirus 2 Testing. Clinical Infectious Diseases. <\/i><a href=\"https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciaa1382\/6127024\">https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciaa1382\/6127024<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study modeling the clinical sensitivity of assays to detect SARS-CoV-2 based on their limits of detection (LoD) found that each 10-fold increase in LoD was expected to lower the assay sensitivity by about 13%. Ct values were obtained from 4,700 SARS-CoV-2 positive patients using the Abbott SARS-CoV-2 EUA test. The authors argue that assays&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/03\/the-limit-of-detection-matters-the-case-for-benchmarking-severe-acute-respiratory-syndrome-coronavirus-2-testing\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27],"topic":[19],"class_list":["post-3664","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3664"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3664\/revisions"}],"predecessor-version":[{"id":3665,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3664\/revisions\/3665"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3664"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}