{"id":3729,"date":"2021-02-05T18:23:56","date_gmt":"2021-02-06T02:23:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3729"},"modified":"2021-02-22T22:37:50","modified_gmt":"2021-02-23T06:37:50","slug":"large-scale-analysis-of-sars-cov-2-spike-glycoprotein-mutants-demonstrates-the-need-for-continuous-screening-of-virus-isolates","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/05\/large-scale-analysis-of-sars-cov-2-spike-glycoprotein-mutants-demonstrates-the-need-for-continuous-screening-of-virus-isolates\/","title":{"rendered":"Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates"},"content":{"rendered":"<p><i>[Pre-print, not peer reviewed]<\/i> An analysis of SARS-CoV-2 genome sequences from around the world found that the overall rate of non-synonymous mutations in the spike protein was low. While only 14% of the samples contained no variation from the reference sequence, fewer than 10 non-synonymous mutations were found in 99.98% of samples. Recurrent variations were common and were distributed throughout the spike genome. The mean and median number of spike protein mutations per sample increased over time, however.<\/p>\n<p><i>Schroers et al. (Feb 4, 2021). Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates. Pre-print downloaded Feb 5 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.02.04.429765\">https:\/\/doi.org\/10.1101\/2021.02.04.429765<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer reviewed] An analysis of SARS-CoV-2 genome sequences from around the world found that the overall rate of non-synonymous mutations in the spike protein was low. While only 14% of the samples contained no variation from the reference sequence, fewer than 10 non-synonymous mutations were found in 99.98% of samples. Recurrent variations were&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/05\/large-scale-analysis-of-sars-cov-2-spike-glycoprotein-mutants-demonstrates-the-need-for-continuous-screening-of-virus-isolates\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[159],"topic":[19],"class_list":["post-3729","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-variants","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3729"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3729\/revisions"}],"predecessor-version":[{"id":3730,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3729\/revisions\/3730"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3729"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}