{"id":3768,"date":"2021-02-08T20:16:43","date_gmt":"2021-02-09T04:16:43","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3768"},"modified":"2021-02-08T20:16:43","modified_gmt":"2021-02-09T04:16:43","slug":"impact-of-systemic-corticosteroids-on-hospitalized-patients-with-covid-19-january-2021-meta-analysis-of-randomized-controlled-trials","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/08\/impact-of-systemic-corticosteroids-on-hospitalized-patients-with-covid-19-january-2021-meta-analysis-of-randomized-controlled-trials\/","title":{"rendered":"Impact of Systemic Corticosteroids on Hospitalized Patients with COVID-19 January 2021 Meta-Analysis of Randomized Controlled Trials"},"content":{"rendered":"<p><i>[Pre-print, not peer-reviewed]<\/i> A meta-analysis of five peer-reviewed randomized controlled trials (n = 7,645 patients) of systemic corticosteroid treatment for COVID-19 showed no overall difference in survival among hospitalized patients who received systemic corticosteroid therapy compared to usual care or placebo (OR =<span class=\"Apple-converted-space\">\u00a0 <\/span>0.82, 95% CI 0.64 \u2013 1.05). Subgroup analysis of 1,967 critically ill patients in the trials showed improved survival in patients who received systemic corticosteroid therapy (OR = 0.67, 95% CI 0.51 \u2013 0.87). The authors note that 3 RCTs were terminated early due to the preliminary results from the RECOVERY trial, which likely impacted the analysis.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Robinson et al. (Feb 5, 2021). Impact of Systemic Corticosteroids on Hospitalized Patients with COVID-19 January 2021 Meta-Analysis of Randomized Controlled Trials. Pre-print downloaded Feb 8 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.02.03.21251065\">https:\/\/doi.org\/10.1101\/2021.02.03.21251065<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A meta-analysis of five peer-reviewed randomized controlled trials (n = 7,645 patients) of systemic corticosteroid treatment for COVID-19 showed no overall difference in survival among hospitalized patients who received systemic corticosteroid therapy compared to usual care or placebo (OR =\u00a0 0.82, 95% CI 0.64 \u2013 1.05). Subgroup analysis of 1,967 critically ill&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/08\/impact-of-systemic-corticosteroids-on-hospitalized-patients-with-covid-19-january-2021-meta-analysis-of-randomized-controlled-trials\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-3768","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3768"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3768\/revisions"}],"predecessor-version":[{"id":3769,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3768\/revisions\/3769"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3768"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3768"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3768"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}