{"id":3831,"date":"2021-02-10T18:30:20","date_gmt":"2021-02-11T02:30:20","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3831"},"modified":"2021-02-11T18:53:43","modified_gmt":"2021-02-12T02:53:43","slug":"sars-cov-2-infection-is-effectively-treated-and-prevented-by-eidd-2801","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/10\/sars-cov-2-infection-is-effectively-treated-and-prevented-by-eidd-2801\/","title":{"rendered":"SARS-CoV-2 Infection Is Effectively Treated and Prevented by EIDD-2801"},"content":{"rendered":"<p>Mice implanted with human lung tissue may serve as an effective animal model to investigate SARS-CoV-2 infection and to test potential treatments and preventive agents. A study of human lung-only mice (LoM) showed that this platform can be used to study SARS-CoV-2 infection <i>in vivo<\/i> in ways that allows direct comparison of outcomes between mice and humans, and that bat coronaviruses could replicate <i>in vivo<\/i> without virus adaptation. The study also explored the effects of EIDD-2801 (molnupiravir), an antiviral medication currently in phase II\u2013III clinical trials, which was found to inhibit SARS-CoV-2 replication in human lung tissue, and prevented infection when administered as pre-exposure prophylaxis. EIDD-2801 reduced the number of infectious particles in lung tissue by 4.4 logs (&gt;25,000 fold decrease) when treatment in the mice was initiated 24 hours post-exposure. Viral titers declined by 96% (1.5 logs) when treatment was started 48 hours post-exposure.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Wahl et al. (Feb 9, 2021). SARS-CoV-2 Infection Is Effectively Treated and Prevented by EIDD-2801. Nature. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03312-w\">https:\/\/doi.org\/10.1038\/s41586-021-03312-w<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mice implanted with human lung tissue may serve as an effective animal model to investigate SARS-CoV-2 infection and to test potential treatments and preventive agents. A study of human lung-only mice (LoM) showed that this platform can be used to study SARS-CoV-2 infection in vivo in ways that allows direct comparison of outcomes between mice&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/10\/sars-cov-2-infection-is-effectively-treated-and-prevented-by-eidd-2801\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-3831","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3831"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3831\/revisions"}],"predecessor-version":[{"id":3832,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3831\/revisions\/3832"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3831"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}