{"id":3937,"date":"2020-01-29T12:12:58","date_gmt":"2020-01-29T20:12:58","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3937"},"modified":"2021-02-16T12:14:23","modified_gmt":"2021-02-16T20:14:23","slug":"genomic-characterisation-and-epidemiology-of-2019-novel-coronavirus-implications-for-virus-origins-and-receptor-binding","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/01\/29\/genomic-characterisation-and-epidemiology-of-2019-novel-coronavirus-implications-for-virus-origins-and-receptor-binding\/","title":{"rendered":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Samples from nine patients, eight with Wuhan travel history, were evaluated. Genome sequence identity between patients was 99.98%. 2019-nCoV had 88% sequence identity (similarity) with two SARS-like coronaviruses with bat origin but was less similar to SARS-CoV (79%) and MERS-CoV (50%). Receptor-binding domain structure was similar to SARS-CoV.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In line with other studies, the virus appears to be within the subgenus Sarbecovirus of genus Betacoronavirus.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">While bats are identified as the likely origin, evidence points to a potential intermediary host sold at the Wuhan seafood market.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lu et al. (Jan 29, 2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)30251-8\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S0140-6736(20)30251-8<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Samples from nine patients, eight with Wuhan travel history, were evaluated. Genome sequence identity between patients was 99.98%. 2019-nCoV had 88% sequence identity (similarity) with two SARS-like coronaviruses with bat origin but was less similar to SARS-CoV (79%) and MERS-CoV (50%). Receptor-binding domain structure was similar to SARS-CoV.\u00a0 In line with other studies, the virus&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/01\/29\/genomic-characterisation-and-epidemiology-of-2019-novel-coronavirus-implications-for-virus-origins-and-receptor-binding\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[165],"class_list":["post-3937","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-origins-reservoir-and-virus-background"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3937"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3937\/revisions"}],"predecessor-version":[{"id":3938,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3937\/revisions\/3938"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3937"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}