{"id":3994,"date":"2020-02-03T13:33:00","date_gmt":"2020-02-03T21:33:00","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=3994"},"modified":"2021-02-16T13:34:21","modified_gmt":"2021-02-16T21:34:21","slug":"the-novel-coronavirus-2019-2019-ncov-uses-the-sars-1-coronavirus-receptor-ace2-and-the-cellular-protease-tmprss2-for-entry-into-target-cells","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/03\/the-novel-coronavirus-2019-2019-ncov-uses-the-sars-1-coronavirus-receptor-ace2-and-the-cellular-protease-tmprss2-for-entry-into-target-cells\/","title":{"rendered":"The novel coronavirus 2019 (2019-nCoV) uses the SARS-1 coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">M Hoffman, <\/span><i><span style=\"font-weight: 400\">et al<\/span><\/i><span style=\"font-weight: 400\">. found that 2019-nCoV uses the same receptor, ACE2, used by SARS viruses to invade host cells; and that another cellular protease may be part of the process, presenting another potential target for therapy. They also consider how similarities with SARS may translate to 2019-nCoV transmission and pathogenicity.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Sera from a convalescent SARS patient partially inhibited 2019-nCov entry into target cells <\/span><i><span style=\"font-weight: 400\">in vitro<\/span><\/i><span style=\"font-weight: 400\">.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Extrapulmonary SARS-CoV spread in ACE2-expressing tissues was observed, and should be assessed for 2019-nCoV. The role of an additional protein (TMPRSS2) in 2019n-CoV entry may affect these comparisons.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Hoffman M, et al. (31 Jan, 2020). The novel coronavirus 2019 (2019-nCoV) uses the SARS-1 coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. Pre-Print. <\/span><\/i><i><span style=\"font-weight: 400\"><br \/>\n<\/span><\/i><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.01.31.929042v1\"><i><span style=\"font-weight: 400\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.01.31.929042v1<\/span><\/i><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>M Hoffman, et al. found that 2019-nCoV uses the same receptor, ACE2, used by SARS viruses to invade host cells; and that another cellular protease may be part of the process, presenting another potential target for therapy. They also consider how similarities with SARS may translate to 2019-nCoV transmission and pathogenicity. Sera from a convalescent&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/03\/the-novel-coronavirus-2019-2019-ncov-uses-the-sars-1-coronavirus-receptor-ace2-and-the-cellular-protease-tmprss2-for-entry-into-target-cells\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[165],"class_list":["post-3994","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-origins-reservoir-and-virus-background"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=3994"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3994\/revisions"}],"predecessor-version":[{"id":3995,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/3994\/revisions\/3995"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=3994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=3994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=3994"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=3994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}