{"id":4017,"date":"2020-02-04T13:54:24","date_gmt":"2020-02-04T21:54:24","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4017"},"modified":"2021-02-16T13:55:27","modified_gmt":"2021-02-16T21:55:27","slug":"fast-assessment-of-human-receptor-binding-capability-of-2019-novel-coronavirus-2019-ncov","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/04\/fast-assessment-of-human-receptor-binding-capability-of-2019-novel-coronavirus-2019-ncov\/","title":{"rendered":"Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV)"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Huang and Herrman perform large-scale protein-protein docking experiments to quantify the interactions of 2019-nCoV S-protein receptor-binding domain (S-RBD) with human receptor ACE2\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Sampling a large number of thermodynamically probable binding conformations with Monte Carlo algorithm, they established an experiment-based strength reference for evaluating the receptor-binding affinity of 2019-nCoV via comparison with SARS-CoV.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The binding affinity of 2019-nCoV S-RBD was about 73% of that of SARS-CoV<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This method might also be applied for rapidly assessing human transmission capability of other newly emerging CoV; and shows the utility of protein-protein interaction analyses<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Huang Q and Herrman A (Feb 4, 2020). Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV). Pre-Print downloaded on 4 Feb, 2020 from, <\/span><\/i><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.01.930537v2\"><span style=\"font-weight: 400\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.01.930537v2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huang and Herrman perform large-scale protein-protein docking experiments to quantify the interactions of 2019-nCoV S-protein receptor-binding domain (S-RBD) with human receptor ACE2\u00a0 Sampling a large number of thermodynamically probable binding conformations with Monte Carlo algorithm, they established an experiment-based strength reference for evaluating the receptor-binding affinity of 2019-nCoV via comparison with SARS-CoV.\u00a0 The binding affinity&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/04\/fast-assessment-of-human-receptor-binding-capability-of-2019-novel-coronavirus-2019-ncov\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[178],"class_list":["post-4017","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-virology"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4017"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4017\/revisions"}],"predecessor-version":[{"id":4018,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4017\/revisions\/4018"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4017"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}