{"id":4019,"date":"2020-02-04T13:55:56","date_gmt":"2020-02-04T21:55:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4019"},"modified":"2021-02-16T13:57:06","modified_gmt":"2021-02-16T21:57:06","slug":"an-emerging-coronavirus-causing-pneumonia-outbreak-in-wuhan-china-calling-for-developing-therapeutic-and-prophylactic-strategies","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/04\/an-emerging-coronavirus-causing-pneumonia-outbreak-in-wuhan-china-calling-for-developing-therapeutic-and-prophylactic-strategies\/","title":{"rendered":"An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Jiang, et al. provide a review of sequence homologies among SARS, MERS, and bat-SL-CoV\u2019s related to 2019-nCoV strains in order to predict the potential utility of viral replication inhibitors found effective for SARS and MERS in animal models\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">They align 2019-nCoV S protein sequence with those of SARS-CoV and several bat-SL-CoVs to predict the cleavage site for generating S1 and S2 subunits; likely functioning of those subunits; and specific candidate molecules to interfere with viral replication<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Two functional domains of the S1 subunit: binding of the virion to the host cell receptor\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Three functional domains of the S2 subunit: fusion between viral and cellular membranes<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Jiang S, et al. (2020) An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies, Emerging Microbes &amp; Infections. 9:1, 275-277, DOI: 10.1080\/22221751.2020.1723441<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jiang, et al. provide a review of sequence homologies among SARS, MERS, and bat-SL-CoV\u2019s related to 2019-nCoV strains in order to predict the potential utility of viral replication inhibitors found effective for SARS and MERS in animal models\u00a0 They align 2019-nCoV S protein sequence with those of SARS-CoV and several bat-SL-CoVs to predict the cleavage&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/04\/an-emerging-coronavirus-causing-pneumonia-outbreak-in-wuhan-china-calling-for-developing-therapeutic-and-prophylactic-strategies\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[178],"class_list":["post-4019","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-virology"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4019"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4019\/revisions"}],"predecessor-version":[{"id":4020,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4019\/revisions\/4020"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4019"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}