{"id":4036,"date":"2020-02-05T14:52:56","date_gmt":"2020-02-05T22:52:56","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4036"},"modified":"2021-02-16T14:54:10","modified_gmt":"2021-02-16T22:54:10","slug":"preliminary-identification-of-potential-vaccine-targets-for-2019-ncov-based-on-sars-cov-immunological-studies","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/preliminary-identification-of-potential-vaccine-targets-for-2019-ncov-based-on-sars-cov-immunological-studies\/","title":{"rendered":"Preliminary identification of potential vaccine targets for 2019-nCoV based on SARS-CoV immunological studies"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Using previously described similarities between 2019-nCoV and SARS-CoV, Ahmed, et al. used SARS-CoV-derived experimentally-determined B- and T-cell epitope data to find epitopes in the S and N structural proteins of 2019-nCoV that were identical between the two viruses.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Epitopes are parts of the virus \u201cseen\u201d by the immune system. By finding comparable sites across the two viruses, the researchers were hoping to leverage what is known about SARS-CoV immunogenicity to identify potential vaccine antigen candidates\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">They found several sites where SARS-CoV epitopes mapped to 2019-nCoV proteins. The areas of the genes for the 2019-nCoV epitopes appeared stable (i.e., no reported mutations to date), making them good vaccine antigen candidates.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Also, based on population coverage criteria for the T-cell epitopes (i.e., considering MHC allele distribution in populations to assess the percentage of individuals within a population likely to elicit an immune response to at least one T cell epitope from the set), use of these epitopes as a vaccine target could provide population coverage of 84% (China) or 94% (global) coverage.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ahmed SF, et al. (Feb 4, 2020). Preliminary identification of potential vaccine targets for <\/span><\/i><i><span style=\"font-weight: 400\">2019-nCoV based on SARS-CoV immunological studies. Pre-Print downloaded on 5 Feb, 2020 from, <\/span><\/i><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.03.933226v1\"><span style=\"font-weight: 400\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.03.933226v1<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using previously described similarities between 2019-nCoV and SARS-CoV, Ahmed, et al. used SARS-CoV-derived experimentally-determined B- and T-cell epitope data to find epitopes in the S and N structural proteins of 2019-nCoV that were identical between the two viruses.\u00a0 Epitopes are parts of the virus \u201cseen\u201d by the immune system. By finding comparable sites across the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/preliminary-identification-of-potential-vaccine-targets-for-2019-ncov-based-on-sars-cov-immunological-studies\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[178],"class_list":["post-4036","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-virology"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4036"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4036\/revisions"}],"predecessor-version":[{"id":4037,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4036\/revisions\/4037"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4036"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}