{"id":4038,"date":"2020-02-05T14:54:32","date_gmt":"2020-02-05T22:54:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4038"},"modified":"2021-02-16T14:56:10","modified_gmt":"2021-02-16T22:56:10","slug":"genomic-variance-of-the-2019-ncov-coronavirus","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/genomic-variance-of-the-2019-ncov-coronavirus\/","title":{"rendered":"Genomic variance of the 2019-nCoV coronavirus"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ceraolo and Giorgi construct an expansive phylogenetic tree of representative <\/span><i><span style=\"font-weight: 400\">coronaviridae<\/span><\/i><span style=\"font-weight: 400\">. They confirm a &gt;99% match among sequenced 2019-nCov isolates; and a 96.2% match between 2019-nCoV and the most closely-related bat coronavirus. While 2019-nCoV sequences were fairly homogenous, at least two hyper-variable genomic areas were identified (ORF 1ab, silent; ORF8, serine\/leucine variation).<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">They also assessed protein homology, finding again considerable similarity between 2019-nCoV and one of the bat CoVs. Envelope, membrane, and nucleocapsid proteins were generally highly conserved.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ceraolo C and Giorgi FM (Feb 4, 2020). Genomic variance of the 2019-nCoV coronavirus. Pre-Print downloaded on 5 Feb, 2020 from, <\/span><\/i><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.02.931162v2\"><span style=\"font-weight: 400\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.02.931162v2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ceraolo and Giorgi construct an expansive phylogenetic tree of representative coronaviridae. They confirm a &gt;99% match among sequenced 2019-nCov isolates; and a 96.2% match between 2019-nCoV and the most closely-related bat coronavirus. While 2019-nCoV sequences were fairly homogenous, at least two hyper-variable genomic areas were identified (ORF 1ab, silent; ORF8, serine\/leucine variation). They also assessed&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/genomic-variance-of-the-2019-ncov-coronavirus\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[178],"class_list":["post-4038","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-virology"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4038"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4038\/revisions"}],"predecessor-version":[{"id":4039,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4038\/revisions\/4039"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4038"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}