{"id":4044,"date":"2020-02-05T14:59:07","date_gmt":"2020-02-05T22:59:07","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4044"},"modified":"2021-02-19T14:30:15","modified_gmt":"2021-02-19T22:30:15","slug":"specific-ace2-expression-in-cholangiocytes-may-cause-liver-damage-after-2019-ncov-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/specific-ace2-expression-in-cholangiocytes-may-cause-liver-damage-after-2019-ncov-infection\/","title":{"rendered":"Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Liver function abnormalities have been observed in some 2019-nCoV patients. Chai, et al. assess potential pathways for this damage given the presumed role ACE2 expression in 2019-nCoV infection.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">They found liver abnormalities of 2019-nCoV patients could involve cholangiocyte dysfunction more than hepatocyte damage. Drug induced and systemic inflammatory response may also have a role.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400;\">Chai X, et al. (Feb 4, 2020). Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage <\/span><\/i><i><span style=\"font-weight: 400;\">After 2019-nCoV Infection. Pre-Print downloaded on 5 Feb, 2020 from, <\/span><\/i><span style=\"font-weight: 400;\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.02.03.931766v1<\/span><i><span style=\"font-weight: 400;\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liver function abnormalities have been observed in some 2019-nCoV patients. Chai, et al. assess potential pathways for this damage given the presumed role ACE2 expression in 2019-nCoV infection.\u00a0 They found liver abnormalities of 2019-nCoV patients could involve cholangiocyte dysfunction more than hepatocyte damage. Drug induced and systemic inflammatory response may also have a role.\u00a0 Chai&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/05\/specific-ace2-expression-in-cholangiocytes-may-cause-liver-damage-after-2019-ncov-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-4044","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4044"}],"version-history":[{"count":2,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4044\/revisions"}],"predecessor-version":[{"id":4417,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4044\/revisions\/4417"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4044"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}