{"id":4087,"date":"2021-02-16T21:31:38","date_gmt":"2021-02-17T05:31:38","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4087"},"modified":"2021-02-22T22:28:48","modified_gmt":"2021-02-23T06:28:48","slug":"s-variant-sars-cov-2-lineage-b1-1-7-is-associated-with-significantly-higher-viral-loads-in-samples-tested-by-thermofisher-taqpath-rt-qpcr","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/16\/s-variant-sars-cov-2-lineage-b1-1-7-is-associated-with-significantly-higher-viral-loads-in-samples-tested-by-thermofisher-taqpath-rt-qpcr\/","title":{"rendered":"S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated with Significantly Higher Viral Loads in Samples Tested by ThermoFisher TaqPath RT-QPCR"},"content":{"rendered":"<p>Individuals infected with the SARS-CoV-2 B.1.1.7 variant (first described in the UK) may have considerably higher viral loads, which could potentially explain the higher transmissibility of this variant. Analysis of 641 SARS-CoV-2 PCR positive samples in the UK from October to November 2020 showed that samples suspected to have the B.1.1.7 variant, identified by a unique test result profile in which the S-gene is not detected (i.e. S-gene target failure or SGTF), had lower cycle threshold (Ct) counts. Significantly more SGTF samples had higher inferred viral loads between 10<sup>7<\/sup> to 10<sup>8<\/sup>, which the authors suggest could translate to median viral loads 10,000-fold higher than non-SGTF samples.<\/p>\n<p><i>Kidd et al. (Feb 13, 2021). S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated with Significantly Higher Viral Loads in Samples Tested by ThermoFisher TaqPath RT-QPCR. The Journal of Infectious Diseases. <\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiab082\">https:\/\/doi.org\/10.1093\/infdis\/jiab082<\/a><i><span class=\"Apple-converted-space\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Individuals infected with the SARS-CoV-2 B.1.1.7 variant (first described in the UK) may have considerably higher viral loads, which could potentially explain the higher transmissibility of this variant. Analysis of 641 SARS-CoV-2 PCR positive samples in the UK from October to November 2020 showed that samples suspected to have the B.1.1.7 variant, identified by a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/16\/s-variant-sars-cov-2-lineage-b1-1-7-is-associated-with-significantly-higher-viral-loads-in-samples-tested-by-thermofisher-taqpath-rt-qpcr\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,159],"topic":[21],"class_list":["post-4087","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4087"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4087\/revisions"}],"predecessor-version":[{"id":4088,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4087\/revisions\/4088"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4087"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}