{"id":4149,"date":"2020-02-10T14:44:26","date_gmt":"2020-02-10T22:44:26","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4149"},"modified":"2021-02-17T17:55:06","modified_gmt":"2021-02-18T01:55:06","slug":"covid-19-literature-situation-report-february-10-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/10\/covid-19-literature-situation-report-february-10-2020\/","title":{"rendered":"COVID-19 Literature Situation Report February 10, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b>A descriptive study of 1,099 2019-nCoV patients in China offers some of the most robust information about clinical characteristics available.\u00a0<\/b><\/li>\n<\/ul>\n<ul>\n<li><b>Mental health of medical staff and the public both in China and other affected countries continue to draw interest in the literature and news media.\u00a0<\/b><\/li>\n<\/ul>\n<ul>\n<li><b>Increasingly, researchers are emphasizing the unreliability of case fatality estimates due to underreporting and under-screening in addition to duration of illness. A new report trying to account for some of this bias estimated a case fatality of less than 1% in China, the lowest estimate to date.<\/b><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Transmission and Global Spread<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4156\" class=\"su-post\">\n<h5 class=\"su-post-title\">Pathogenicity and Transmissibility of 2019-nCoV\u2014A Quick Overview and Comparison with Other Emerging Viruses<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Preliminary data suggest that 2019-nCoV may be about 10% less pathogenic than SARS-CoV and about 40% less than MERS-CoV.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">More research is needed to determine of 2019-nCoV has the same mutation and recombination characteristics found in SARS-CoV or if it is more static like MERS-CoV and to identify key routes of infection, which could be <\/span><i><span style=\"font-weight: 400\">both<\/span><\/i><span style=\"font-weight: 400\"> respiratory and gastrointestinal.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chen (Feb 4, 2020). Pathogenicity and Transmissibility of 2019-nCoV\u2014A Quick Overview and Comparison with Other Emerging Viruses. Microbes and Infection. (pre-proof) <\/span><\/i><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1286457920300265?via%3Dihub\"><span style=\"font-weight: 400\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1286457920300265?via%3Dihub<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4154\" class=\"su-post\">\n<h5 class=\"su-post-title\">The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">565 Japanese citizens were evacuated from Wuhan at the end of January and were screened for 2019-nCoV symptoms (63 symptomatic) and tested (8 tested positive by RT-PCR, 5 of whom were asymptomatic).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Using data from these travelers, researchers estimated the rate of under-ascertainment of cases in Wuhan to be 9.2%. This would suggest a true case fatality far lower than recent estimates, likely closer to 0.3-0.6%.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Nishiura et al. (Feb 4, 2020). The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights. J Clin Med.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.3390\/jcm9020419\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.3390\/jcm9020419<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4152\" class=\"su-post\">\n<h5 class=\"su-post-title\">2019-Novel Coronavirus (2019-nCoV): estimating the case fatality rate \u2013 a word of caution<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Time between diagnosis and death\/recovery in addition to underreporting of cases will have tremendous spatiotemporal variation globally.\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Wuhan case fatality estimates are likely overestimated due to vast underreporting of mild and asymptomatic cases.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Delayed identification of 2019-nCoV deaths outside of Wuhan could mean that case fatality estimated based on non-Wuhan cases underestimate true case fatality.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Geographic differences in case fatality could be related to structural factors, like access to health care and the type of health care available.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Manuel et al. (Feb 7, 2020). 2019-Novel Coronavirus (2019-nCoV): estimating the case fatality rate \u2013 a word of caution. Swiss Med Wkly. <\/span><\/i><a href=\"https:\/\/smw.ch\/article\/doi\/smw.2020.20203\"><span style=\"font-weight: 400\">https:\/\/smw.ch\/article\/doi\/smw.2020.20203<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4150\" class=\"su-post\">\n<h5 class=\"su-post-title\">Incorporating Human Movement Data to Improve Epidemiological Estimates for 2019-nCoV<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Researchers developed a geo-stratified framework for estimating 2019-nCoV transmission dynamics in China, addressing underreporting and under-screening biases affecting Wuhan case counts. They estimate a basic reproductive number of 3.24 in Wuhan before the lockdown on Jan 23.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Cao et al. (Feb 9, 2020). Incorporating Human Movement Data to Improve Epidemiological Estimates for 2019-nCoV. Pre Print downloaded Feb 9 from<\/span><\/i> <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.07.20021071v1\"><span style=\"font-weight: 400\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.07.20021071v1<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Modeling and Prediction<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4158\" class=\"su-post\">\n<h5 class=\"su-post-title\">Analysis of the epidemic growth of the early 2019-nCoV outbreak using internationally confirmed cases<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Using clinical, travel history, and disease progression information for 46 2019-nCoV cases who traveled from Wuhan before Jan 23 and were subsequently confirmed elsewhere, researchers attempted to model transmission dynamics with more precision than previous reports by simulating infection time.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Findings suggest a much higher epidemic growth rate in the early days of the outbreak in Wuhan than previous reports, with a 2.9 day doubling time.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zhao et al. (Feb 9, 2020). Analysis of the epidemic growth of the early 2019-nCoV outbreak using internationally confirmed cases. Pre Print downloaded Feb 10 from <\/span><\/i><a href=\"http:\/\/dx.doi.org\/10.1101\/2020.02.06.20020941\"><span style=\"font-weight: 400\">http:\/\/dx.doi.org\/10.1101\/2020.02.06.20020941<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4176\" class=\"su-post\">\n<h5 class=\"su-post-title\">Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Researchers developed two 1-step real-time RT PCR assays for the Sarbecovirus subgenus to account for potential genetic diversity of the 2019-nCoV circulating in humans. Assays were tested on respiratory samples and results are promising. Further testing is needed.<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Lo and Chiu offer some commentary and critique of this earlier report and opportunities for further testing.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chu et al. (Jan 31, 2020). Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia. Clinical Chemistry. <\/span><\/i><a href=\"https:\/\/academic.oup.com\/clinchem\/advance-article\/doi\/10.1093\/clinchem\/hvaa029\/5719336\"><span style=\"font-weight: 400\">https:\/\/academic.oup.com\/clinchem\/advance-article\/doi\/10.1093\/clinchem\/hvaa029\/5719336<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<p><i><span style=\"font-weight: 400\">Lo and Rossa (Feb 7, 2020).<\/span><\/i><em><span style=\"font-weight: 400\"> Racing towards the development of diagnostics for a novel coronavirus (2019-nCoV). Clinical Chemistry. <\/span><\/em><a href=\"https:\/\/academic.oup.com\/clinchem\/advance-article\/doi\/10.1093\/clinchem\/hvaa038\/5729988\"><span style=\"font-weight: 400\">https:\/\/academic.oup.com\/clinchem\/advance-article\/doi\/10.1093\/clinchem\/hvaa038\/5729988<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4174\" class=\"su-post\">\n<h5 class=\"su-post-title\">A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Following WHO rules for guideline development, this team developed rapid advice guidelines for 2019-nCoV that include epidemiologic characteristics along with recommendations for disease screening and population prevention, diagnosis, treatment and control, nosocomial infection prevention and control, and nursing.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This rich tool includes some specific information from Zhongnan Hospital of Wuhan University.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Jin et al. (Feb 6, 2020). A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research. <\/span><\/i><a href=\"https:\/\/mmrjournal.biomedcentral.com\/articles\/10.1186\/s40779-020-0233-6\"><span style=\"font-weight: 400\">https:\/\/mmrjournal.biomedcentral.com\/articles\/10.1186\/s40779-020-0233-6<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4172\" class=\"su-post\">\n<h5 class=\"su-post-title\">Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Authors conducted a literature review to determine the ability of coronaviruses to persist on inanimate objects, with potential applications for the current 2019-nCoV outbreak. Both SARS and MERS coronaviruses can persist on inanimate surfaces (fomites) for up to 9 days. They can be inactivated effectively by disinfection procedures with 62-71% ethanol, 0.5% hydrogen peroxide, or 0.1% sodium hypochlorite within one minute.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Kampf et al. (Feb 6, 2020). Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents. J of Hosp Infect. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jhin.2020.01.022\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.jhin.2020.01.022<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4170\" class=\"su-post\">\n<h5 class=\"su-post-title\">A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A Chinese team provides recommendations for addressing 2019-nCoV preparedness and response in neonatology intensive care units based on prior experiences with coronavirus outbreaks.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang et al. (Feb 7, 2020). A contingency plan for the management of the 2019 novel <\/span><\/i><i><span style=\"font-weight: 400\">coronavirus outbreak in neonatal intensive care units. The Lancet. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S2352-4642(20)30040-7\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S2352-4642(20)30040-7<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4168\" class=\"su-post\">\n<h5 class=\"su-post-title\">Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Clinical characteristics of 15 2019-nCoV patients outside of Wuhan are described.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chang et al. (Feb 7, 2020). Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China. JAMA Research Letter. <\/span><\/i><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2761043?resultClick=1\"><span style=\"font-weight: 400\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2761043?resultClick=1<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4166\" class=\"su-post\">\n<h5 class=\"su-post-title\">CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">CT imaging for two 2019-nCoV patients demonstrate changes over the duration of disease.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Fang et al. (Feb 7, 2020). CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology<\/span><\/i><span style=\"font-weight: 400\">. <\/span><a href=\"https:\/\/pubs.rsna.org\/doi\/10.1148\/radiol.2020200280\"><span style=\"font-weight: 400\">https:\/\/pubs.rsna.org\/doi\/10.1148\/radiol.2020200280<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4164\" class=\"su-post\">\n<h5 class=\"su-post-title\">Evolving status of the 2019 novel coronavirus Infection: proposal of conventional serologic assays for disease diagnosis and infection monitoring<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Researchers explain the need for developing serological assays for 2019-nCoV testing. Real-time RT-PCR or next-generation sequencing are the primary methods for confirming 2019-nCoV infection, but with limited supplies, the number of cases that can be tested is restricted and delayed. Researchers propose conventional serological assays as a potential alternative.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A backlog of tests in China produces artificial jumps in daily case reports.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Sensitivity and specificity of the predominant testing methods have not been assessed yet.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Xiao et al. (Feb 7, 2020). Evolving status of the 2019 novel coronavirus Infection: proposal of conventional serologic assays for disease diagnosis and infection monitoring. J Med Virology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/jmv.25702\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1002\/jmv.25702<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4162\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clinical characteristics of 2019 novel coronavirus infection in China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Clinical characteristics of 1,099 laboratory-confirmed 2019-nCoV patients at 552 hospitals across China (through Jan 29) are described in relation to disease severity and a composite endpoint of ICU admission, mechanical ventilation, and death. Disease severity (including oxygen saturation, respiratory rate, blood leukocyte\/lymphocyte count, and chest X-ray\/CT manifestations) predicts clinical outcomes<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Median age of 47 years (only 9 cases below 15 years old)<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">41.8% female<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">1.18% had direct contact with wildlife<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">31.3% had been to Wuhan; 71.8% had contact with someone who had been to Wuhan<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Symptoms: Fever (87.9%), cough (67.7%), fatigue (38.1%). Diarrhea, uncommon<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Median incubation period = 3 days (range 0-24)<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">76.4% had various chest CT abnormalities<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">79.1% developed pneumonia<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Median time from symptom onset to pneumonia diagnosis 4 days (range 2-4)<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">1.4% had died at time of publication\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Guan et al. (Feb 9, 2020). Clinical characteristics of 2019 novel coronavirus infection in China. Pre Print downloaded Feb 9 from <\/span><\/i><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.06.20020974v1\"><span style=\"font-weight: 400\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.06.20020974v1<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4160\" class=\"su-post\">\n<h5 class=\"su-post-title\">The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In reviewing the importation of the first 2019-nCoV case to Korea, clinicians call for testing all symptomatic individuals with epidemiologic risk for 2019-nCoV rather than waiting for pneumonia or other symptoms to develop. They describe potential flaws of relying on chest radiography and clinical cues, urging clinicians to prioritize travel history to improve early detection and isolation.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Kim et al. (Feb 10, 2020). The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures. J Korean Med Sci.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.3346\/jkms.2020.35.e61\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.3346\/jkms.2020.35.e61<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Virology<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4180\" class=\"su-post\">\n<h5 class=\"su-post-title\">Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The 2019-nCoV virus genome has undergone in-depth annotation, and differences between the virus and SARS and SARS-like coronaviruses are described. These differences may explain functional and pathogenic differences between the viruses.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wu et al (Feb 7, 2020). Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host &amp; Microbe. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.chom.2020.02.001\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.chom.2020.02.001<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4178\" class=\"su-post\">\n<h5 class=\"su-post-title\">Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-I<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Researchers re-analyzed data reported in two prior papers that suggested snakes are an intermediary host for 2019-nCov. Their results do not support this conclusion, pointing instead to mammals and birds as more likely intermediary hosts. Findings also indicated that the previously reported \u201cunlikely\u201d similarity between a 2019-nCoV spike protein insertion and that of HIV-I was actually the result of natural evolution from bat coronaviruses.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zhang et al. (Feb 8, 2020). Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-I. Pre Print downloaded Feb 10 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.02.04.933135\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.02.04.933135<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Mental Health and Personal Impact<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4186\" class=\"su-post\">\n<h5 class=\"su-post-title\">The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In this commentary, authors discuss the mental health effects experienced by medical workers in Wuhan during the current outbreak and the steps taken by local government and health care facility officials to support them.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Kang et al. (Feb 5, 2020). The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus. The Lancet.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.1016\/S2215-0366(20)30047-X\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S2215-0366(20)30047-X<\/span><\/a><span style=\"font-weight: 400\">\u00a0\u00a0\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4184\" class=\"su-post\">\n<h5 class=\"su-post-title\">In Beijing, coronavirus 2019-nCoV has created a siege mentality<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This commentary describes the difficult conditions and social environment in Beijing, with some emphasis on the experiences of clinical staff at regional hospitals.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Mowbray (Feb 7, 2020). In Beijing, coronavirus 2019-nCoV has created a siege mentality. BMJ.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.1136\/bmj.m516\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1136\/bmj.m516<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4182\" class=\"su-post\">\n<h5 class=\"su-post-title\">Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: mental health consequences and target populations<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Social and economic impacts of the 2019-nCoV outbreak are discussed. They are contextualized within the history of emergencies in the region, including atomic bombings, sarin gas attacks, H1N1, and the Fukushima nuclear accident. Anxiety disorders, PTSD, depression, somatization, lower perceived health, public fear, discrimination, and stigmatization are key highlighted as challenges.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Shigemura et al. (Feb 8, 2020 ). Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: mental health consequences and target populations. Psychiatry and Clinical Neurosciences.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.1111\/pcn.12988\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1111\/pcn.12988<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A descriptive study of 1,099 2019-nCoV patients in China offers some of the most robust information about clinical characteristics available.\u00a0<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/10\/public-responses-to-the-novel-2019-coronavirus-2019-ncov-in-japan-mental-health-consequences-and-target-populations\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":2773,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-4149","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4149"}],"version-history":[{"count":3,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4149\/revisions"}],"predecessor-version":[{"id":4310,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4149\/revisions\/4310"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/2773"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4149"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}