{"id":4191,"date":"2020-02-11T15:23:16","date_gmt":"2020-02-11T23:23:16","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4191"},"modified":"2021-02-22T12:02:26","modified_gmt":"2021-02-22T20:02:26","slug":"covid-19-literature-situation-report-february-10-2020-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/11\/covid-19-literature-situation-report-february-10-2020-2\/","title":{"rendered":"COVID-19 Literature Situation Report February 11, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b>The possibility of asymptomatic transmission remains an open question.<\/b><\/li>\n<\/ul>\n<ul>\n<li><b>Modeling of influenza and comparisons to other recently emergent coronavirus epidemics indicate that the US must prepare for the implications of sustained transmission of a highly transmissible and relatively severe new virus.<\/b><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400\"><b>The Substance Abuse and Mental Health Services Administration has helpful, web-based resources related to mental health during infectious disease outbreaks.<\/b><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Transmission and Global Spread<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4196\" class=\"su-post\">\n<h5 class=\"su-post-title\">Transmission and epidemiological characteristics of Novel Coronavirus (2019-nCoV)-Infected Pneumonia (NCIP):preliminary evidence obtained in comparison with 2003-SARS<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Updating a previously-posted pre-print, Zhang, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> describe their analysis comparing 2019-nCoV pneumonia (NCIP) to 2003-SARS cases to guide prevention and control of the former. Data included public information on Chinese NCIP cases (n=287; age 9-90 years old; male:female ratio, 1.35:1). Compared to SARS, NCIP has a lower case fatality rate and a higher \u201ccure rate\u201d. Fatality rates were higher in Wuhan compared to elsewhere in China (1.5 to 6.6% and 0 to 2.6%, respectively).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zhang, et al. (Feb 10, 2020) Transmission and epidemiological characteristics of Novel Coronavirus (2019-nCoV)-Infected Pneumonia (NCIP):preliminary evidence obtained in comparison with 2003-SARS. Pre-print downloaded 10 February from <\/span><\/i><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.01.30.20019836v2\"><span style=\"font-weight: 400\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.01.30.20019836v2<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4194\" class=\"su-post\">\n<h5 class=\"su-post-title\">The first 2019 novel coronavirus case in Nepal<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Bastola, et al. provide a case report of the first confirmed 2019-nCoV case in Nepal. The case was a student in Wuhan returning to Nepal six days after symptom onset on 3 January, 2020. [<\/span><i><span style=\"font-weight: 400\">Note:<\/span><\/i><span style=\"font-weight: 400\"> Potential inconsistency, implies that case left China on 9 Jan (by air) and arrived in Nepal on 13 Jan.]<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Case presentation and resolution are consistent with spectrum of disease in hospitalized patients described elsewhere, noting he was on the mild end of this spectrum compared to others from early to mid-January. Follow-up RT-PCR on throat swabs were negative by 29 and 30 January.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Bastola, et al. (Feb 10, 2020) The first 2019 novel coronavirus case in Nepal. Lancet Infect Dis. Published online, <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S1473-3099(20)30067-0\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S1473-3099(20)30067-0<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4192\" class=\"su-post\">\n<h5 class=\"su-post-title\">Transmission of 2019-nCoV infection from an asymptomatic contact in Germany<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Rothe, <\/span><i><span style=\"font-weight: 400\">et al<\/span><\/i><span style=\"font-weight: 400\">. have provided supplementary information regarding their NEJM Correspondence from 31 January, 2020 that reported asymptomatic transmission between a Chinese business traveler and colleagues in Germany. This supplement follows news reports that Bavarian officials found the index case to be potentially symptomatic during her time in Germany. The supplement provides new detail on the Chinese index case\u2019s symptom timeline, based on a 5 February, 2020 interview with the case.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The index patient from China visited Germany and attended business meeting from 19-22 January, 2020. Per the original paper, \u201cDuring her stay, she had been well with no signs or symptoms of infection but had become ill on her flight back to China\u2026\u201d The added information includes, among other updates, that:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Around midnight on 20 January, after awakening feeling \u201cwarm\u201d but not \u201cfebrile,\u201d the index case took an acetaminophen-containing medication\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Around 3 pm on 21 January, she felt fatigue \u2013 which she attributed to jet lag \u2013 and \u201c\u2026noticed \u2026minor pain \u2018in some muscles and the bones of her chest\u2019 when [touching] trigger points\u201d<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">After her arrival in Shanghai, on 23 January, was the first time she reported feeling sick.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Roth, et al. make no further comment on the original paper, supplying only the added timeline.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Supplement to: Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. Available from: <\/span><\/i><a href=\"https:\/\/www.nejm.org\/doi\/suppl\/10.1056\/NEJMc2001468\/suppl_file\/nejmc2001468_appendix.pdf\"><span style=\"font-weight: 400\">https:\/\/www.nejm.org\/doi\/suppl\/10.1056\/NEJMc2001468\/suppl_file\/nejmc2001468_appendix.pdf<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Modeling and Prediction<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4198\" class=\"su-post\">\n<h5 class=\"su-post-title\">Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus: Lessons From Previous Epidemics<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Swerdlow and Finelli review information from modeling studies of earlier epidemics and pandemics to assess global preparedness for sustained transmission of an emerging viral disease with high transmissibility and severity. Examples cited were H1N1, SARS-CoV, and MERS-CoV.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Models suggest that:\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Assuming no intervention in a US population, a model mixing a range of influenza transmission and severity parameters indicated that clinical attack rates of 20-30% (per H1N1pdm09) could lead to 669,000-4,300,000 hospitalizations and 54,000-538,000 deaths, depending on severity.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Without a vaccine, school closures would be unlikely to affect spread.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">35,000-60,000 ventilators would be needed, as would ~7.3 billion surgical masks\/respirators<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vaccine development <\/span><i><span style=\"font-weight: 400\">before<\/span><\/i><span style=\"font-weight: 400\"> introduction of the new pathogen would be required to avoid a significant number of hospitalizations and deaths.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">It is too early in the 2019-nCoV epidemic to determine the combination of transmissibility and severity posed by this virus. However, influenza mitigation plans would be useful to enact should the US see sustained 2019-nCoV transmission.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Swerdlow DL and Finelli L (Feb 11, 2020) Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus: Lessons From Previous Epidemics. JAMA. <\/span><\/i><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2761285\"><span style=\"font-weight: 400\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2761285<\/span><\/a> <i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4200\" class=\"su-post\">\n<h5 class=\"su-post-title\">Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A case series of four 2019-nCoV pneumonia patients admitted to the Shanghai Public Health Clinical Center is presented. Patient recruitment was 21-24 Jan, and data collection occurred through 4 Feb, 2020.\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">All patients had mild to severe pneumonia with fever. Older patients were hospitalized for longer. Other symptoms, laboratory findings, and treatment regimens are summarized.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">All four patients were given supplemental oxygen and were treated with allopathic medicine antivirals (combined lopinavir\/ritonavir, arbidol); a Chinese traditional medicine, Shufeng Jiedu Capsule (SFJDC); and antibiotics (not specified).<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The most severe case (63 year old female) was placed on mechanical ventilation and received human seroalbumin and gamma-immunoglobulin.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang, et al. (Feb 6, 2020). Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. BioScience Trends. <\/span><\/i><a href=\"https:\/\/doi.org\/10.5582\/bst.2020.01030\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.5582\/bst.2020.01030<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Policy and Prevention<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4204\" class=\"su-post\">\n<h5 class=\"su-post-title\">Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Lee and Hsueh review the emergence of the zoonotic coronaviruses SARS, MERS, and 2019-nCoV. They provide a high level review of reservoirs, mechanisms of infection, routes of transmission, clinical presentation and pandemic potential, with an emphasis on using this information to inform current 2019-nCoV containment.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lee P-I and Hsueh P-R (Feb 4, 2020). Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV, Journal of Microbiology, Immunology and Infection. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.jmii.2020.02.001\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.jmii.2020.02.001<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-4202\" class=\"su-post\">\n<h5 class=\"su-post-title\">A qualitative study of zoonotic risk factors among rural communities in southern China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In a qualitative evaluation of general zoonotic transmission risk factors in rural China, Li, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> present information from predominantly agrarian communities. Interesting findings include:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Dogs or cats kept for companionship, home protection or preventing rat infestations\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Poultry, pigs and cattle raised for meat consumption; animal waste sometimes used as crop fertilizer; seeking medical treatment for bites and scratches was uncommon\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vaccination coverage of domestic animals was low. Participants were informed about rabies but rarely other zoonotic illnesses.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">While participants reported a decrease in wild animal hunting, trading or consumption activities, hunting or consumption of some wild animals (e.g. rodents, bats, civets, frogs, snakes and birds) still occurred<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Recent infrastructure improvements and inspections of designated slaughter houses were recognized to have improved hygiene and sanitation conditions. Poultry slaughter and sale in wet markets remained a concern.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Bat caves and roosts close to human dwellings were reported; wild animals among crops were observed.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mitigation opportunities through gun control policies, enforcement of wildlife protection laws were reported to have reduced wildlife hunting. Healthcare access to local government clinics was generally good. Access to government-provided free or low-priced vaccines for domestic animals was limited\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Li, et al. (Feb 10, 2020). A qualitative study of zoonotic risk factors among rural communities in southern China. International Health. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/inthealth\/ihaa001\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/inthealth\/ihaa001<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Mental Health and Personal Impact<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-4206\" class=\"su-post\">\n<h5 class=\"su-post-title\">Substance Abuse and Mental Health Services Administration Resources<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The Substance Abuse and Mental Health Services Administration has three helpful resources related to mental health during infectious disease outbreaks. These were developed in response to previous events to support community members and may be particularly helpful as WA continues to stand up quarantine processes for 2019-nCoV outbreak response.\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/store.samhsa.gov\/system\/files\/sma14-4894.pdf\"><span style=\"font-weight: 400\">Taking Care of Your Behavioral Health: Tips for Social Distancing, Quarantine, and Isolation During an Infectious Disease Outbreak<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/store.samhsa.gov\/system\/files\/sma14-4885.pdf\"><span style=\"font-weight: 400\">Coping with Stress During Infectious Disease Outbreaks<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/store.samhsa.gov\/system\/files\/sma14-4886.pdf\"><span style=\"font-weight: 400\">Taking with Children: Tips for Caregivers, Parents, and Teachers During Infectious Disease Outbreak<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Per multiple news sites, <\/span><a href=\"https:\/\/www.npr.org\/sections\/goatsandsoda\/2020\/02\/11\/802352351\/new-coronavirus-gets-an-official-name-from-the-world-health-organization\"><span style=\"font-weight: 400\">including NPR<\/span><\/a><span style=\"font-weight: 400\">, the WHO has announced the official name of the emergent 2019-nCoV to be COVID-19. This name will be used as appropriate in future literature reviews.<\/span><\/li>\n<\/ul>\n<p><strong><i>Need to get caught up?\u00a0<\/i><\/strong><\/p>\n<ul>\n<li><span style=\"font-weight: 400\">Malik, et al. provide a review of the emerging 2019-nCoV focusing on its genetics, likely evolution, and antigen profile \u2013 relating this last to developing vaccine and therapeutics. Implications for disease control are discussed.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Malik YS, et al. (Feb 8, 2020). Emerging novel Coronavirus (2019-nCoV) &#8211; Current scenario, evolutionary perspective based on genome analysis and recent developments, Veterinary Quarterly. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/01652176.2020.1727993\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1080\/01652176.2020.1727993<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Arabi, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> provide a review of critical care management for adults with severe respiratory viral infections, including antiviral therapies, other pharmacologic interventions, supportive care, and infection control measures. The review covers a spectrum of common respiratory viruses (e.g., influenza, hCoVs, RSV) and emerging or re-emerging viruses (e.g., measles, hanta, and 2019-nCoV)\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Arabi YM, et al. (Feb 10, 2020)<\/span><\/i> <i><span style=\"font-weight: 400\">Critical care management of adults with community<\/span><\/i><i><span style=\"font-weight: 400\">\u2011<\/span><\/i><i><span style=\"font-weight: 400\">acquired severe respiratory viral infection, Intensive Care Med, <\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s00134-020-05943-5\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1007\/s00134-020-05943-5<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The possibility of asymptomatic transmission remains an open question.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/11\/substance-abuse-and-mental-health-services-administration-resources\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":340,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-4191","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4191"}],"version-history":[{"count":4,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4191\/revisions"}],"predecessor-version":[{"id":4498,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4191\/revisions\/4498"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/340"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4191"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}