{"id":4217,"date":"2020-02-12T15:46:16","date_gmt":"2020-02-12T23:46:16","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4217"},"modified":"2021-02-19T16:16:39","modified_gmt":"2021-02-20T00:16:39","slug":"epidemiological-and-clinical-features-of-the-2019-novel-coronavirus-outbreak-in-china","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/12\/epidemiological-and-clinical-features-of-the-2019-novel-coronavirus-outbreak-in-china\/","title":{"rendered":"Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A review of all 2019-nCoV patients reported to the Chinese Center for Disease Control and Prevention (Chinese CDC) up to 26 January, 2020 was undertaken to describe the affected populations and to estimate severity and transmissibility.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Of 8866 patients, 4021 (45%) were laboratory confirmed.\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ages were similar between confirmed and suspect cases (49 years; SD, <\/span><span style=\"font-weight: 400\">+<\/span><span style=\"font-weight: 400\">16 yrs). Fourteen of the 4021 confirmed cases were in children &lt;10 years old. Most confirmed cases were 30-65 years of age.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Wuhan patients were on average older and more likely to be male compared to elsewhere in China.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Among confirmed cases, median time from symptom onset to diagnosis was 5 days. Mild pneumonia (70%) was most often seen at time of diagnosis, with about 26% diagnosed with severe pneumonia and 5% with no evidence of pneumonia.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Incidence shifted from sporadic to exponential on 1 January. Starting 17 January, more confirmed patients were reported outside of Wuhan than in Wuhan.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Bias-adjusted Case Fatality Rate (CFR) estimates:\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Among confirmed cases, calculated CFRs were higher than observed CFRs (3.1% and 1.4%, respectively).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ranged from 0.7% for those with mild disease at time of diagnosis to 9.5% for patients with two of three risks (male, <\/span><span style=\"font-weight: 400\">&gt;<\/span><span style=\"font-weight: 400\">60 years of age, or severe disease at diagnosis)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Were higher in patients <\/span><span style=\"font-weight: 400\">&gt;<\/span><span style=\"font-weight: 400\">60 years of age (5.3% vs. 1.4% &lt;60 yrs), patients with longer time from onset to diagnosis (3.1%, &gt;5 days vs. 1.3%, <\/span><span style=\"font-weight: 400\">&lt;<\/span><span style=\"font-weight: 400\">5), and among males (4.5% vs. 1.3%)<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">R<\/span><span style=\"font-weight: 400\">0<\/span><span style=\"font-weight: 400\"> estimates were highest (R<\/span><span style=\"font-weight: 400\">0<\/span><span style=\"font-weight: 400\">, 3.2-4.8) for long incubation (6.4 days) and infectious (9.2 days) periods; and lowest (R<\/span><span style=\"font-weight: 400\">0<\/span><span style=\"font-weight: 400\">, 2.2-2.8) for short incubation (3.8 days) and infectious (5.2 days) periods, with added variability due to reporting rate(30%-100%).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Yang Y, et al (Feb 11, 2020) Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. Pre-print accessed Feb 12 from <\/span><\/i><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.10.20021675v1\"><span style=\"font-weight: 400\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.02.10.20021675v1<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A review of all 2019-nCoV patients reported to the Chinese Center for Disease Control and Prevention (Chinese CDC) up to 26 January, 2020 was undertaken to describe the affected populations and to estimate severity and transmissibility. Of 8866 patients, 4021 (45%) were laboratory confirmed.\u00a0 Ages were similar between confirmed and suspect cases (49 years; SD,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/12\/epidemiological-and-clinical-features-of-the-2019-novel-coronavirus-outbreak-in-china\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[21],"class_list":["post-4217","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4217"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4217\/revisions"}],"predecessor-version":[{"id":4218,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4217\/revisions\/4218"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4217"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}