{"id":4229,"date":"2020-02-12T15:54:15","date_gmt":"2020-02-12T23:54:15","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4229"},"modified":"2021-02-19T16:22:40","modified_gmt":"2021-02-20T00:22:40","slug":"on-the-use-of-corticosteroids-for-2019-ncov-pneumonia","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/12\/on-the-use-of-corticosteroids-for-2019-ncov-pneumonia\/","title":{"rendered":"On the use of corticosteroids for 2019-nCoV pneumonia"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Shang, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> respond to an earlier article by Russell, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> on clinical evidence of corticosteroid therapy in severe coronavirus infections. Shang, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> describe the potential for selection bias and confounding in observational studies, given that usually only critically ill patients are treated with corticosteroid therapy. They further note that four references in the original articles cited as having \u201cconclusive data\u2026indicating harm\u201d were not definitive, and that Russell, <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> did not address 25 other inconclusive studies. Additional studies supporting low-moderate dose corticosteroid therapy for severely ill coronavirus and influenza patients are cited.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An expert consensus statement from the Chinese Thoracic Society identifies basic principles for corticosteroids use, including that corticosteroids can be used prudently in critically ill COVID-2019 patients, with special caution for patients with hypoxemia due to underlying diseases or who regularly use corticosteroids for chronic diseases; that dosage should be low-to-moderate (\u22640\u00b75\u20131 mg\/kg per day methylprednisolone or equivalent); and that duration should be short (\u22647 days).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Shang L, et al. (Feb 11, 2020) On the use of corticosteroids for 2019-nCoV pneumonia. The Lancet. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)30361-5\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S0140-6736(20)30361-5<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shang, et al. respond to an earlier article by Russell, et al. on clinical evidence of corticosteroid therapy in severe coronavirus infections. Shang, et al. describe the potential for selection bias and confounding in observational studies, given that usually only critically ill patients are treated with corticosteroid therapy. They further note that four references in&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/12\/on-the-use-of-corticosteroids-for-2019-ncov-pneumonia\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-4229","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4229"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4229\/revisions"}],"predecessor-version":[{"id":4230,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4229\/revisions\/4230"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4229"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}