{"id":4434,"date":"2021-02-18T19:43:04","date_gmt":"2021-02-19T03:43:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4434"},"modified":"2021-02-22T21:39:13","modified_gmt":"2021-02-23T05:39:13","slug":"neutralizing-activity-of-bnt162b2-elicited-serum-preliminary-report","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/18\/neutralizing-activity-of-bnt162b2-elicited-serum-preliminary-report\/","title":{"rendered":"Neutralizing Activity of BNT162b2-Elicited Serum \u2014 Preliminary Report"},"content":{"rendered":"<p>Neutralizing activity of sera from recipients of the 2-dose Pfizer vaccine (n=15, 20 serum samples) against wild-type SARS-CoV-2 (USA-WA1\/2020) engineered with the full set of spike protein mutations of the B.1.351 variant was weaker than the USA-WA1\/2020 strain by approximately two-thirds. Using 50% plaque reduction neutralization testing (PRNT50) on sera obtained 2-4 weeks after the second dose, geometric mean titers against USA-WA1\/2020, USA-WA1\/2020 with the globally dominant D614G mutation, USA-WA1\/2020 with key B.1.351 mutations (K417N, E484K, and N501Y), and USA-WA1\/2020 with the full set of B.1.351 mutations were 501, 485, 331, and 184, respectively.<\/p>\n<p><i>Liu et al.\u00a0(Feb 17, 2021). Neutralizing Activity of BNT162b2-Elicited Serum \u2014 Preliminary Report. New England Journal of Medicine. <\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2102017\">https:\/\/doi.org\/10.1056\/NEJMc2102017<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neutralizing activity of sera from recipients of the 2-dose Pfizer vaccine (n=15, 20 serum samples) against wild-type SARS-CoV-2 (USA-WA1\/2020) engineered with the full set of spike protein mutations of the B.1.351 variant was weaker than the USA-WA1\/2020 strain by approximately two-thirds. Using 50% plaque reduction neutralization testing (PRNT50) on sera obtained 2-4 weeks after the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/18\/neutralizing-activity-of-bnt162b2-elicited-serum-preliminary-report\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33,159],"topic":[31],"class_list":["post-4434","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4434"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4434\/revisions"}],"predecessor-version":[{"id":4435,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4434\/revisions\/4435"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4434"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}