{"id":4438,"date":"2021-02-18T19:45:45","date_gmt":"2021-02-19T03:45:45","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4438"},"modified":"2021-02-22T21:36:58","modified_gmt":"2021-02-23T05:36:58","slug":"serum-neutralizing-activity-elicited-by-mrna-1273-vaccine-preliminary-report","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/18\/serum-neutralizing-activity-elicited-by-mrna-1273-vaccine-preliminary-report\/","title":{"rendered":"Serum Neutralizing Activity Elicited by MRNA-1273 Vaccine \u2014 Preliminary Report"},"content":{"rendered":"<p>Neutralizing activity of sera from recipients of the 2-dose Moderna vaccine in the phase 1 trial (n=45) were similar against a SARS-CoV-2 pseudovirus bearing the spike protein from the original Wuhan-Hu-1 isolate, the D614G variant, as well as against 20E (EU1), 20A.EU2, N439K-D614G, and mink cluster 5 variants. In contrast, neutralizing titers against the D614G variant decreased 2.7-fold against a pseudovirus with a partial set of the mutations in the B.1.351 variant (mutations K417N, E484K, and N501Y), and by 6.4-fold against the full set of B.1.351 mutations. Sera obtained from 8 participants still neutralized the B.1.351 variant at low dilutions. <i>[EDITORIAL NOTE: This article was summarized as a pre-print on January 25, 2021.]<\/i><\/p>\n<p><i>Wu et al.\u00a0(Feb 17, 2021). Serum Neutralizing Activity Elicited by MRNA-1273 Vaccine \u2014 Preliminary Report. New England Journal of Medicine. <\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2102179\">https:\/\/doi.org\/10.1056\/NEJMc2102179<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neutralizing activity of sera from recipients of the 2-dose Moderna vaccine in the phase 1 trial (n=45) were similar against a SARS-CoV-2 pseudovirus bearing the spike protein from the original Wuhan-Hu-1 isolate, the D614G variant, as well as against 20E (EU1), 20A.EU2, N439K-D614G, and mink cluster 5 variants. In contrast, neutralizing titers against the D614G&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/18\/serum-neutralizing-activity-elicited-by-mrna-1273-vaccine-preliminary-report\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33,159],"topic":[31],"class_list":["post-4438","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4438"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4438\/revisions"}],"predecessor-version":[{"id":4439,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4438\/revisions\/4439"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4438"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}