{"id":4745,"date":"2020-02-28T13:31:21","date_gmt":"2020-02-28T21:31:21","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=4745"},"modified":"2021-02-23T13:32:41","modified_gmt":"2021-02-23T21:32:41","slug":"a-systematic-review-of-lopinavir-therapy-for-sars-coronavirus-and-mers-coronavirus-a-possible-reference-for-coronavirus-disease-19-treatment-option","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/28\/a-systematic-review-of-lopinavir-therapy-for-sars-coronavirus-and-mers-coronavirus-a-possible-reference-for-coronavirus-disease-19-treatment-option\/","title":{"rendered":"A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus\u2013A Possible Reference for Coronavirus Disease-19 Treatment Option"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In absence of FDA-approved antiviral therapies for COVID-19, Yao et al reviewed efficacy of Lopinavir (LPV), an agent used during SARS and MERS epidemic, to clarify its potential for use in patients with COVID-19. Currently a combination of LPV\/r is a recommended treatment in China. They reported on two reviews; one with success on limited patients and bigger study with variable outcome. They call for more clinically valid evidence (RCT) to confirm the positive value of LPV for COVID-19 treatment. Adverse reaction including diarrhea, nausea, and asthenia were frequently reported among other symptoms.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Yao et al. (Feb 27, 2020). A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus\u2013A Possible Reference for Coronavirus Disease-19 Treatment Option.\u00a0 Journal of Medical Virology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/jmv.25729\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1002\/jmv.25729<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In absence of FDA-approved antiviral therapies for COVID-19, Yao et al reviewed efficacy of Lopinavir (LPV), an agent used during SARS and MERS epidemic, to clarify its potential for use in patients with COVID-19. Currently a combination of LPV\/r is a recommended treatment in China. They reported on two reviews; one with success on limited&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/02\/28\/a-systematic-review-of-lopinavir-therapy-for-sars-coronavirus-and-mers-coronavirus-a-possible-reference-for-coronavirus-disease-19-treatment-option\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-4745","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=4745"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4745\/revisions"}],"predecessor-version":[{"id":4746,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/4745\/revisions\/4746"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=4745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=4745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=4745"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=4745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}