{"id":5000,"date":"2020-03-12T15:28:46","date_gmt":"2020-03-12T22:28:46","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5000"},"modified":"2021-02-24T15:43:30","modified_gmt":"2021-02-24T23:43:30","slug":"covid-19-literature-situation-report-march-12-2020","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/03\/12\/covid-19-literature-situation-report-march-12-2020\/","title":{"rendered":"COVID-19 Literature Situation Report March 12, 2020"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b>One study calls attention to clinical recommendations during the current outbreak for psoriasis patients who may be on immunosuppressive treatments.\u00a0\u00a0<\/b><\/li>\n<li><b>In line with prior reports, another article finds no evidence of vertical transmission of SARS-CoV-2 virus during pregnancy while also emphasizing the importance of effective protective measures during delivery.\u00a0<\/b><\/li>\n<li><b>A new study emphasizes the need for more detailed contact investigations to improve our understanding of COVID-19 transmissibility.\u00a0<\/b><\/li>\n<li><b>Several papers in recent days have outlined the importance of hospital preparedness for COVID-19 and have proposed protocols to support these efforts.\u00a0<\/b><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Transmission<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-5005\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV-2 Infection among Travelers returning from Wuhan, China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In this correspondence based on a follow-up on 94 people who boarded an evacuation flight from Wuhan to Singapore on Jan 30<\/span><span style=\"font-weight: 400\">th<\/span><span style=\"font-weight: 400\">, the authors highlight the importance of understanding transmission of COVID-19 from asymptomatic people or those with very mild symptoms for successful containment strategies.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ng et al. (Mar 12, 2020). SARS-CoV-2 Infection among Travelers returning from Wuhan, China. The New England Journal of Medicine.<\/span><\/i> <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2003100\"><span style=\"font-weight: 400\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2003100<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5003\" class=\"su-post\">\n<h5 class=\"su-post-title\">Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This article reiterates that mother-to-child transmission of SARS-CoV-2 is unlikely and highlights the importance of effective implementation of protective measures during delivery.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Li et al. (Mar 5, 2020). Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China. Emerging Infectious Disease. <\/span><\/i><a href=\"https:\/\/doi.org\/10.3201\/eid2606.200287\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.3201\/eid2606.200287<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5001\" class=\"su-post\">\n<h5 class=\"su-post-title\">First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This article describes the epidemiologic investigation and contact tracing that was conducted on this first person-to-person transmission in the U.S. that occurred between two people with prolonged, unprotected exposure while the index patient (travel-associated case) was symptomatic.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The authors note that despite actively monitoring almost 350 contacts and the 75 contacts who further developed COVID-19 symptoms during the 14-day incubation period, all of them tested negative for COVID-19.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Further detailed reports of contact investigations could improve understanding of the transmissibility of this novel virus.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ghinai et al. (Mar 12, 2020). First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA. The Lancet. <\/span><\/i><i><span style=\"font-weight: 400\"><br \/>\n<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)30607-3\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S0140-6736(20)30607-3<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-5007\" class=\"su-post\">\n<h5 class=\"su-post-title\">COVID-19 and psoriasis: is it time to limit treatment with immunosuppressants? A call for action<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The authors stress the importance of a therapeutic reassessment of all psoriatic patients because immunosuppressive drugs can weaken the immune system making these patients more susceptible to opportunistic infections.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Conforti et al. (Mar 11, 2020). COVID-19 and psoriasis: is it time to limit treatment with immunosuppressants? A call for action. Dermatologic Therapy. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/dth.13298\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1111\/dth.13298<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-5017\" class=\"su-post\">\n<h5 class=\"su-post-title\">Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Wong et al describe potential outbreak response measures for tertiary level acute care hospitals preparing for COVID-19.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wong et al. (Mar 4, 2020). Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore. Canadian Journal of Anesthesia.<\/span><\/i> <a href=\"https:\/\/doi.org\/10.1007\/s12630-020-01620-9\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1007\/s12630-020-01620-9<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5015\" class=\"su-post\">\n<h5 class=\"su-post-title\">Detection of Covid-19 in Children in Early January 2020 in Wuhan, China<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This retrospective analysis of 366 children hospitalized in Wuhan early in the COVID-19 outbreak found that the most frequent pathogen identified was influenza A. 6 patients tested positive for COVID-19, presenting with moderate-to-severe symptoms. The findings indicate the COVID-19 infections in children were occurring early in the epidemic.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Liu et al (Mar 12, 2020). Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. The New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2003717\"><span style=\"font-weight: 400\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2003717<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5013\" class=\"su-post\">\n<h5 class=\"su-post-title\">Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Klompas emphasizes the need for hospitals to have more aggressive policies on respiratory hygiene and bolstering restrictions on patients, visitors, and health care workers to prevent further spread of COVID-19.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Klompas (Mar 11, 2020). Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible. Annals of Internal Medicine. <\/span><\/i><a href=\"https:\/\/annals.org\/aim\/fullarticle\/2763036\/coronavirus-disease-2019-covid-19-protecting-hospitals-from-invisible\"><span style=\"font-weight: 400\">Article available here<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5011\" class=\"su-post\">\n<h5 class=\"su-post-title\">How Should U.S. Hospitals Prepare for Coronavirus Disease 2019 (COVID-19)?<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The authors describe detailed strategies for hospitals to consider when developing their preparedness plans for COVID-19.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chopra et al. (Mar 11, 2020). How Should U.S. Hospitals Prepare for Coronavirus Disease 2019 (COVID-19)? Annals of Internal Medicine. <\/span><\/i><a href=\"https:\/\/annals.org\/aim\/fullarticle\/2763037\/how-should-u-s-hospitals-prepare-coronavirus-disease-2019-covid\"><span style=\"font-weight: 400\">Article available here<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-5009\" class=\"su-post\">\n<h5 class=\"su-post-title\">2019 novel coronavirus patients\u2019 clinical characteristics, discharge rate and fatality rate of meta-analysis<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Li et al summarize clinical data from 10 studies to describe the clinical symptoms, laboratory test data, and epidemiological characteristics of about 2,000 COVID-19 patients. The results of the meta-analysis showed that men accounted for 60% of COVID-19 patients, which was higher than women, and the case fatality was 7%.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Li et al. (Mar 12, 2020). 2019 novel coronavirus patients\u2019 clinical characteristics, discharge rate and fatality rate of meta-analysis. Journal of Medical Virology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1002\/jmv.25757\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1002\/jmv.25757<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><strong>Other Resources and Commentaries<\/strong><\/h3>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMp2003539\"><span style=\"font-weight: 400\">Virtually perfect? Telemedicine for COVID-19<\/span><\/a><span style=\"font-weight: 400\"> \u2013 NEJM (Mar 12)<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hollander et al list out various reasons why telemedicine is a great solution for COVID-19.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/uog.22013\"><span style=\"font-weight: 400\">ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Ultrasound in Obstetrics &amp; Gynecology (Mar 11)<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In addition to providing interim guidance on COVID-19, the article mentions that while there is no evidence that pregnant women are more susceptible to COVID-19 infection or that those with COVID-19 are more prone to developing severe pneumonia, the case fatality among pregnant women may be up to 25%. However, note that further research on pregnancy and birth effects of COVID-19 is warranted.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www1.health.gov.au\/internet\/main\/publishing.nsf\/Content\/1D03BCB527F40C8BCA258503000302EB\/$File\/covid_19_au_epi_report_6_reporting_week_ending_1900_aedt_7_march_2020.pdf\"><span style=\"font-weight: 400\">COVID-19, Australia: Epidemiology Report 6<\/span><\/a><span style=\"font-weight: 400\"> \u2013 (Mar 7) This is the sixth epidemiological report for COVID-19 reported in Australia\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>One study calls attention to clinical recommendations during the current outbreak for psoriasis patients who may be on immunosuppressive treatments.  <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/03\/12\/2019-novel-coronavirus-patients-clinical-characteristics-discharge-rate-and-fatality-rate-of-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":341,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-5000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5000"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5000\/revisions"}],"predecessor-version":[{"id":5020,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5000\/revisions\/5020"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/341"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5000"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}