{"id":5218,"date":"2021-02-26T21:20:42","date_gmt":"2021-02-27T05:20:42","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5218"},"modified":"2021-02-26T21:20:42","modified_gmt":"2021-02-27T05:20:42","slug":"seasonal-human-coronavirus-antibodies-are-boosted-upon-sars-cov-2-infection-but-not-associated-with-protection-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/26\/seasonal-human-coronavirus-antibodies-are-boosted-upon-sars-cov-2-infection-but-not-associated-with-protection-2\/","title":{"rendered":"Seasonal Human Coronavirus Antibodies Are Boosted upon SARS-CoV-2 Infection but Not Associated with Protection"},"content":{"rendered":"<ul>\n<li>Cross reactive antibodies generated by pre-pandemic human coronavirus (hCoV) infections are common but are not associated with protection against infection or poor clinical outcomes after infection with SARS-CoV-2. Using samples from a pre-pandemic biobank, 4% of pre-pandemic sera contained antibodies that bound the full-length spike from SARS-CoV-2 and 16% of samples contained antibodies capable of binding SARS-CoV-2 nucleocapsid. Pre-pandemic serum containing these antibodies was wholly incapable of neutralizing SARS-CoV-2 in either pseudovirus or live virus assays. The baseline presence or absence of non-neutralizing cross-reactive antibodies was not associated with protection against SARS-CoV-2 infection or clinical outcomes after infection in a cohort of 251 participants who went on to develop SARS-CoV-2. Levels of some of these hCoV antibodies were boosted upon infection with SARS-CoV-2.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i>Anderson et al. (Feb 9, 2021). Seasonal Human Coronavirus Antibodies Are Boosted upon SARS-CoV-2 Infection but Not Associated with Protection. Cell. <\/i><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.02.010\">https:\/\/doi.org\/10.1016\/j.cell.2021.02.010<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cross reactive antibodies generated by pre-pandemic human coronavirus (hCoV) infections are common but are not associated with protection against infection or poor clinical outcomes after infection with SARS-CoV-2. Using samples from a pre-pandemic biobank, 4% of pre-pandemic sera contained antibodies that bound the full-length spike from SARS-CoV-2 and 16% of samples contained antibodies capable of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/02\/26\/seasonal-human-coronavirus-antibodies-are-boosted-upon-sars-cov-2-infection-but-not-associated-with-protection-2\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32],"topic":[31],"class_list":["post-5218","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5218"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5218\/revisions"}],"predecessor-version":[{"id":5219,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5218\/revisions\/5219"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5218"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}