{"id":5242,"date":"2021-03-01T01:15:39","date_gmt":"2021-03-01T09:15:39","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5242"},"modified":"2021-03-02T01:16:39","modified_gmt":"2021-03-02T09:16:39","slug":"sars-cov-2-spike-d614g-change-enhances-replication-and-transmission","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/01\/sars-cov-2-spike-d614g-change-enhances-replication-and-transmission\/","title":{"rendered":"SARS-CoV-2 Spike D614G Change Enhances Replication and Transmission"},"content":{"rendered":"<ul>\n<li>The SARS-CoV-2 S-614G variant was found to enhance binding to recombinant human ACE2 receptors, increase replication in lung and nasal cell culture systems, increase replication in a humanized ACE2 mouse model, and increased transmissibility in hamster and ferret SARS-CoV-2 models. While this mutation resulted in small increases in binding and replication in vitro, it conferred larger competitive advantages in vivo, potentially explaining the increased prevalence of this strain.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i>Zhou et al. (Feb 26, 2021). SARS-CoV-2 Spike D614G Change Enhances Replication and Transmission. Nature. <\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03361-1\">https:\/\/doi.org\/10.1038\/s41586-021-03361-1<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The SARS-CoV-2 S-614G variant was found to enhance binding to recombinant human ACE2 receptors, increase replication in lung and nasal cell culture systems, increase replication in a humanized ACE2 mouse model, and increased transmissibility in hamster and ferret SARS-CoV-2 models. While this mutation resulted in small increases in binding and replication in vitro, it conferred&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/01\/sars-cov-2-spike-d614g-change-enhances-replication-and-transmission\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[159],"topic":[21],"class_list":["post-5242","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5242"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5242\/revisions"}],"predecessor-version":[{"id":5243,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5242\/revisions\/5243"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5242"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}