{"id":5248,"date":"2021-03-01T01:21:04","date_gmt":"2021-03-01T09:21:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5248"},"modified":"2021-03-02T01:31:31","modified_gmt":"2021-03-02T09:31:31","slug":"effect-of-previous-sars-cov-2-infection-on-humoral-and-t-cell-responses-to-single-dose-bnt162b2-vaccine","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/01\/effect-of-previous-sars-cov-2-infection-on-humoral-and-t-cell-responses-to-single-dose-bnt162b2-vaccine\/","title":{"rendered":"Effect of Previous SARS-CoV-2 Infection on Humoral and T-Cell Responses to Single-Dose BNT162b2 Vaccine"},"content":{"rendered":"<ul>\n<li>Individuals with prior SARS-CoV-2 infection generated strong humoral and cellular responses following a single dose of the Pfizer\/BioNTech vaccine, according to an analysis of specimens from healthcare workers in the UK (n = 72).<span class=\"Apple-converted-space\">\u00a0 <\/span>Individuals who had not been previously infected showed weaker T-cell responses and generated lower neutralizing antibody titers (median 615.1 vs. 16353 arbitrary units [AU]\/mL).\u00a0Using a T-cell enzyme-linked immunospot assay, vaccine recipients with evidence of prior infection at baseline (n=21) were found to have strong T-cell responses to spike peptides, whereas responses were significantly weaker among infection-naive vaccine recipients (n=30). 24 (50%) of 48 all recipients generated responses that could be considered negative.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i>Prendecki et al. (Feb 26, 2021). Effect of Previous SARS-CoV-2 Infection on Humoral and T-Cell Responses to Single-Dose BNT162b2 Vaccine. The Lancet. <\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(21)00502-X\">https:\/\/doi.org\/10.1016\/S0140-6736(21)00502-X<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Individuals with prior SARS-CoV-2 infection generated strong humoral and cellular responses following a single dose of the Pfizer\/BioNTech vaccine, according to an analysis of specimens from healthcare workers in the UK (n = 72).\u00a0 Individuals who had not been previously infected showed weaker T-cell responses and generated lower neutralizing antibody titers (median 615.1 vs. 16353&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/01\/effect-of-previous-sars-cov-2-infection-on-humoral-and-t-cell-responses-to-single-dose-bnt162b2-vaccine\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33],"topic":[31],"class_list":["post-5248","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5248"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5248\/revisions"}],"predecessor-version":[{"id":5249,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5248\/revisions\/5249"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5248"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}