{"id":537,"date":"2020-08-26T19:49:17","date_gmt":"2020-08-27T02:49:17","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=537"},"modified":"2020-08-31T19:50:30","modified_gmt":"2020-09-01T02:50:30","slug":"antibody-responses-and-clinical-outcomes-in-adults-hospitalized-with-severe-covid-19-a-post-hoc-analysis-of-lotus-china-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/26\/antibody-responses-and-clinical-outcomes-in-adults-hospitalized-with-severe-covid-19-a-post-hoc-analysis-of-lotus-china-trial\/","title":{"rendered":"Antibody Responses and Clinical Outcomes in Adults Hospitalized with Severe COVID-19: A Post Hoc Analysis of LOTUS China Trial"},"content":{"rendered":"<ul>\n<li>Patients with severe COVID-19 (n=191) enrolled in the LOTUS China trial testing lopinavir for suppression of SARS-CoV-2 nearly all (&gt;90%) developed IgM and IgG antibodies against nucleocapsid (N), spike protein (S), and the receptor-binding domain (RBD), and also produced neutralizing antibodies (NAbs), but these did not correlate clearly with clinical outcomes. The levels of IgG antibodies against N, S and RBD were related to viral clearance. The NAbs titers increased over time in both survivors and non-survivors and correlated with IgG antibodies against N, S and RBD, but NAbs titers were not associated with viral load or survival, indicating that NAbs might not be sufficient for the viral clearance of SARS-CoV-2 during disease progression.<\/li>\n<\/ul>\n<p>Ren et al. (Aug 25, 2020). Antibody Responses and Clinical Outcomes in Adults Hospitalized with Severe COVID-19: A Post <em>Hoc Analysis of LOTUS China Trial. Clinical Infectious Diseases. <a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1247\">https:\/\/doi.org\/10.1093\/cid\/ciaa1247<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patients with severe COVID-19 (n=191) enrolled in the LOTUS China trial testing lopinavir for suppression of SARS-CoV-2 nearly all (&gt;90%) developed IgM and IgG antibodies against nucleocapsid (N), spike protein (S), and the receptor-binding domain (RBD), and also produced neutralizing antibodies (NAbs), but these did not correlate clearly with clinical outcomes. The levels of IgG&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/26\/antibody-responses-and-clinical-outcomes-in-adults-hospitalized-with-severe-covid-19-a-post-hoc-analysis-of-lotus-china-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34],"topic":[31],"class_list":["post-537","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=537"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/537\/revisions"}],"predecessor-version":[{"id":538,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/537\/revisions\/538"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=537"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}