{"id":5547,"date":"2021-03-02T23:17:09","date_gmt":"2021-03-03T07:17:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5547"},"modified":"2021-03-02T23:17:09","modified_gmt":"2021-03-03T07:17:09","slug":"evaluation-of-a-sars-cov-2-vaccine-nvx-cov2373-in-younger-and-older-adults","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/02\/evaluation-of-a-sars-cov-2-vaccine-nvx-cov2373-in-younger-and-older-adults\/","title":{"rendered":"Evaluation of a SARS-CoV-2 Vaccine NVX-CoV2373 in Younger and Older Adults"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> The two-dose Novavax recombinant nanoparticle vaccine candidate \u201cNVX-CoV2373\u201d induced robust IgG-anti-spike protein and neutralizing antibody titers against SARS-CoV-2 in both young and older participants, according to results from a Phase I\/II trial (n=1,283). &gt;98% of participants had seroconversion in both age groups fourteen days after the second dose. Reactogenicity was predominantly mild to moderate in severity and short in duration (median &lt;3 days) after the first dose, with adverse events occurring in higher frequencies and intensities after the second dose among those receiving the 25-ug dose regimen.<\/li>\n<\/ul>\n<p><i>Formica et al.\u00a0(Mar 1, 2021). Evaluation of a SARS-CoV-2 Vaccine NVX-CoV2373 in Younger and Older Adults. Pre-print downloaded Mar 2 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.02.26.21252482\">https:\/\/doi.org\/10.1101\/2021.02.26.21252482<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] The two-dose Novavax recombinant nanoparticle vaccine candidate \u201cNVX-CoV2373\u201d induced robust IgG-anti-spike protein and neutralizing antibody titers against SARS-CoV-2 in both young and older participants, according to results from a Phase I\/II trial (n=1,283). &gt;98% of participants had seroconversion in both age groups fourteen days after the second dose. Reactogenicity was predominantly mild&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/02\/evaluation-of-a-sars-cov-2-vaccine-nvx-cov2373-in-younger-and-older-adults\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33],"topic":[31],"class_list":["post-5547","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5547"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5547\/revisions"}],"predecessor-version":[{"id":5548,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5547\/revisions\/5548"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5547"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}