{"id":5555,"date":"2021-03-02T23:21:12","date_gmt":"2021-03-03T07:21:12","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5555"},"modified":"2021-03-02T23:21:12","modified_gmt":"2021-03-03T07:21:12","slug":"negligible-impact-of-sars-cov-2-variants-on-cd4-and-cd8-t-cell-reactivity-in-covid-19-exposed-donors-and-vaccinees","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/02\/negligible-impact-of-sars-cov-2-variants-on-cd4-and-cd8-t-cell-reactivity-in-covid-19-exposed-donors-and-vaccinees\/","title":{"rendered":"Negligible Impact of SARS-CoV-2 Variants on CD4+ and CD8+ T Cell Reactivity in COVID-19 Exposed Donors and Vaccinees"},"content":{"rendered":"<ul>\n<li><i>[Pre-print, not peer-reviewed]<\/i> Bioinformatic analysis suggests that memory T cells generated either by mild SARS-CoV-2 infection (n=11) or mRNA vaccines will not be affected by currently circulating variants. No significant differences were found in the capacity of CD4+ or CD8+ T cells isolated either from convalescent patients following mild disease or vaccinated individuals to recognize a pool of S protein peptides in any lineage tested. These peptides corresponded either to the parental reference SARS-CoV-2 strain isolated from Wuhan or the different variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C.<\/li>\n<\/ul>\n<p><i>Tarke et al.\u00a0(Mar 1, 2021). Negligible Impact of SARS-CoV-2 Variants on CD4+ and CD8+ T Cell Reactivity in COVID-19 Exposed Donors and Vaccinees. Pre-print downloaded Mar 2 from <\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.02.27.433180\">https:\/\/doi.org\/10.1101\/2021.02.27.433180<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Bioinformatic analysis suggests that memory T cells generated either by mild SARS-CoV-2 infection (n=11) or mRNA vaccines will not be affected by currently circulating variants. No significant differences were found in the capacity of CD4+ or CD8+ T cells isolated either from convalescent patients following mild disease or vaccinated individuals to recognize&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/03\/02\/negligible-impact-of-sars-cov-2-variants-on-cd4-and-cd8-t-cell-reactivity-in-covid-19-exposed-donors-and-vaccinees\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33,159],"topic":[31],"class_list":["post-5555","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5555"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5555\/revisions"}],"predecessor-version":[{"id":5556,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5555\/revisions\/5556"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5555"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}