{"id":5587,"date":"2020-04-01T14:15:34","date_gmt":"2020-04-01T21:15:34","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=5587"},"modified":"2021-03-03T14:23:42","modified_gmt":"2021-03-03T22:23:42","slug":"cigarette-smoke-triggers-the-expansion-of-a-subpopulation-of-respiratory-epithelial-cells-that-express-the-sars-cov-2-receptor-ace2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/01\/cigarette-smoke-triggers-the-expansion-of-a-subpopulation-of-respiratory-epithelial-cells-that-express-the-sars-cov-2-receptor-ace2\/","title":{"rendered":"Cigarette smoke triggers the expansion of a subpopulation of respiratory epithelial cells that express the SARS-CoV-2 receptor ACE2"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Smith and Sheltzer report that cigarette smoke triggers a protective expansion of mucus-secreting goblet cells and the expansion of a subpopulation of respiratory epithelial cells that express the SARS-CoV-2 receptor; Angiotensin Converting Enzyme 2 (ACE2). These results may partially explain why smokers are particularly likely to develop severe SARS-CoV-2 infections, and suggest that quitting smoking could lessen coronavirus susceptibility.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Smith and Sheltzer. (Mar 30, 2020). Cigarette smoke triggers the expansion of a subpopulation of respiratory epithelial cells that express the SARS-CoV-2 receptor ACE2. Pre-print downloaded Apr 1 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.03.28.013672\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2020.03.28.013672<\/span><\/a><i><span style=\"font-weight: 400\">\u00a0<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Smith and Sheltzer report that cigarette smoke triggers a protective expansion of mucus-secreting goblet cells and the expansion of a subpopulation of respiratory epithelial cells that express the SARS-CoV-2 receptor; Angiotensin Converting Enzyme 2 (ACE2). These results may partially explain why smokers are particularly likely to develop severe SARS-CoV-2 infections, and suggest that quitting smoking&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/04\/01\/cigarette-smoke-triggers-the-expansion-of-a-subpopulation-of-respiratory-epithelial-cells-that-express-the-sars-cov-2-receptor-ace2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-5587","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=5587"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5587\/revisions"}],"predecessor-version":[{"id":5588,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/5587\/revisions\/5588"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=5587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=5587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=5587"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=5587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}